Products Zolmitriptan is commercially available as film-coated tablets, meltable tablets, and as a nasal spray (Zomig, generics). It has been approved in many countries since 1997. Generic versions entered the market in 2012. Structure and properties Zolmitriptan (C16H21N3O2, Mr = 287.4 g/mol) is an indole and oxazolidinone derivative structurally related to serotonin. It exists as … Zolmitriptan
Products In many countries, drugs containing ergotamine are currently no longer on the market. The active ingredient was available in tablet form in combination with caffeine, among other products (Cafergot), but was withdrawn from the market in 2014. Products containing ergotamine were first launched in the 1920s (Gynergen). Structure and properties Ergotamine (C33H35N5O5, Mr = … Ergotamine
Products The marketing of medicinal products containing dihydroergotamine has been discontinued in many countries (e.g., Dihydergot tablets and nasal spray, Ergotonin, Effortil plus, Old Tonopan, and others). The approval of Dihydergot tablets was cancelled on February 1, 2014, because the benefits no longer outweighed the potential risks, according to drug regulators. Structure and properties Dihydroergotamine … Dihydroergotamine
Products Dihydroergocriptine is no longer registered in many countries. Cripar is out of commerce. Effects Dihydroergocriptine (ATC N04BC03) is dopaminergic and acts selectively on D2 receptors. It has no activity on serotoninergic or adrenergic receptors. Indications Parkinson’s disease Early stages of Parkinson’s disease, as monotherapy or in combination with an L-dopa preparation. Interval treatment of … Dihydroergocriptine
Products Medicinal mushrooms are commercially available, for example, in the form of capsules, tablets and as powders as dietary supplements or as individually prepared mixtures. Also used are the pure ingredients that are extracted, synthetically produced or semi-synthetically modified. These are usually registered as medicinal products. About mushrooms Fungi are a very diverse group of … Medicinal Mushrooms
Products Codergocrine was commercially available in tablet form, as a dropper solution, and as a solution for injection (Hydergin). It had been approved in many countries since 1949. Structure and properties Codergocrine is present in drugs as codergocrine mesilate, a white to yellowish powder that is sparingly soluble in water. It is a mixture of … Codergocrine
Products Cabergoline is commercially available in tablet form (Cabaser, Dostinex). It has been approved in many countries since 1995. Structure and properties Cabergoline (C26H37N5O2, Mr = 451.6 g/mol) is a dopaminergic ergoline derivative. It exists as a white crystalline powder that is practically insoluble in water. Effects Cabergoline (ATC N04BC06) has dopaminergic properties and reduces … Cabergoline
Symptoms Medication-overuse headache, depending on the preexisting symptoms, manifests, for example, like a tension headache as bilateral, pressing pain, or like a migraine, unilateral, pulsating, and accompanied by nausea, vomiting, and sensitivity to light and noise. The pain occurs chronically for at least 15 days of the month, every other day or daily. When the … Medication Overuse Headache
Shadow Medication Regulatory-approved drugs are well documented with patient and professional information and scientific research. They have a brand name and are managed, promoted, and distributed by a company. They are available in pharmacies and drugstores and can be ordered from wholesalers or directly from the company. In addition to these official drugs, there is … Shadow Drugs
Indications Dementia, e.g., Alzheimer’s disease Agents Cholinesterase inhibitors: Donepezil (Aricept, generics). Galantamine (Reminyl) Rivastigmine (Exelon) NMDA antagonists: Memantine (Axura, Ebixa). Ergot alkaloids: Codergocrine (Hydergine, out of commerce). Smart Drugs Roborantia Phytopharmaceuticals: Ginkgo
Products Methylergometrine is commercially available as a solution for injection (Methergin). Distribution of the drops was discontinued in 2011 and that of the dragées in 2018. Structure and properties Methylergometrine (C20H25N3O2, Mr = 339.4 g/mol) is a semisynthetic derivative of the natural alkaloid ergometrine. It is present in the drug as methyl ergometrine maleate. Effects … Methylergometrine
Products Bromocriptine is commercially available in tablet form (Parlodel). It was developed at Sandoz in the 1960s and has been approved in many countries since 1975. Generic versions are now available in many countries. Structure and properties Bromocriptine (C32H40BrN5O5, Mr = 654.6 g/mol) is a brominated derivative of the natural ergot alkaloid ergocryptine. It is … Bromocriptine
