glibenclamide

Sulfonylureas: Drug Effects, Side Effects, Dosage and Uses

Effects Sulfonylureas (ATC A10BB) have antidiabetic, antihyperglycemic, and insulin secretagogue properties. Active Ingredients 1st generation: Tolbutamide, acetohexamide, tolazamide (all off-label). Chlorpropamide (Diabiformin, out of commerce). 2nd generation: Glibenclamide (Daonil, generic). Glibornuride (Glutril, off label). Glipizide (Glibenese, out of trade) Gliclazide (Diamicron /-MR, generic). 3rd generation: Glimepiride (Amaryl, generic). Cf. Diabetes mellitus type 2, glinides

Moxifloxacin

Products Moxifloxacin is commercially available in the form of film-coated tablets, as an infusion solution, and eye drops (Avalox, Vigamox eye drops). It has been approved in many countries since 1999. Generic versions of the tablets went on sale in 2014. This article refers to oral administration; see also moxifloxacin eye drops. Structure and properties … Moxifloxacin

Glibenclamide

Products Glibenclamide is commercially available in tablet form (Daonil, generics). It has been approved in many countries since 1970 and is also used in fixed combination with metformin (Glucovance). Structure and properties Glibenclamide (C23H28ClN3O5S, Mr = 494.0 g/mol) is a sulfonylurea. It exists as a white crystalline powder that is practically insoluble in water. Effects … Glibenclamide

Gliclazide

Products Gliclazide has been commercially available in sustained-release tablet form and approved in many countries since 1978. The sustained-release dosage forms entered the market in 2001. In addition to the original Diamicron MR, sustained-release generics have been available since 2008. Sales of the non-retarded Diamicron 80 mg were discontinued in 2012. Structure and properties Gliclazide … Gliclazide

Antidiabetics

Active ingredients Insulins substitute for endogenous insulin: Human insulin Insulin analogues Biguanides reduce hepatic glucose formation: Metformin (Glucophage, generic). Sulfonylureas promote insulin secretion from beta cells: Glibenclamide (Daonil, generic). Glibornuride (Glutril, off label). Gliclazide (Diamicron, generic). Glimepiride (Amaryl, generics) Glinides promote insulin secretion from beta cells: Repaglinide (NovoNorm, generic). Nateglinide (Starlix) Glitazones decrease peripheral insulin … Antidiabetics

Sulfonylureas

Synonyms Drugs Diabetes mellitus, diabetes drugs, glibenclamide (e.g. Euglucon ®N), glimepiride (e.g. Amaryl®), gliquidone (e.g. Glurenorm®) How do sulfonylureas work? Sulfonylureas stimulate the pancreas to release more insulin. The prerequisite for this, however, is that the beta cells of the pancreas are still capable of producing insulin themselves. When the pancreas is no longer able … Sulfonylureas

When should sulfonylureas not be taken ? | Sulfonylureas

When should sulfonylureas not be taken ? Sulfonylureas must not be taken in case of hypersensitivity to drugs of the sulfonamide type. These include antibiotics used for urinary tract infections (Cotrimoxazole). Some medicines for high blood pressure (diuretics) have a similar origin and have been discontinued by some people due to hypersensitivity. Your doctor will … When should sulfonylureas not be taken ? | Sulfonylureas

Gestational Diabetes

Symptoms Gestational diabetes is a glucose intolerance that is first discovered during pregnancy and is common, occurring in approximately 1-14% of all pregnancies. Typical symptoms of diabetes mellitus such as thirst, frequent urination, and fatigue may occur, but are considered rare. Nonspecific complaints such as increased susceptibility to urinary tract infections may indicate gestational diabetes. … Gestational Diabetes

Bosentan

Products Bosentan is commercially available in the form of tablets and dispersible tablets (Tracleer). It has been approved in many countries since 2002. Generic versions were registered in 2017. Structure and properties Bosentan (C27H29N5O6S, Mr = 551.6 g/mol) is present in drugs as bosentan monohydrate, a white to yellowish powder that is poorly soluble in … Bosentan