Products Cerliponase alfa was approved in the United States in 2017 as a solution for injection (Brineura). The drug’s extremely high price is controversial. Structure and properties Cerliponase alfa is a recombinant tripeptidyl peptidase 1 (rhTPP1) produced by biotechnological methods. Effects Cerliponase alfa replaces the insufficiently active enzyme tripeptidyl peptidase 1 (TPP1) in patients with … Cerliponase Alfa
Products Pitavastatin is commercially available in the form of film-coated tablets (Livazo). It was first approved in many countries in July 2012. In Japan, it has been on the market since 2003, and it is also available in other countries such as the United States and Germany. Structure and properties Pitavastatin (C25H24FNO4, Mr = 421.5 … Pitavastatin
Products Lasmiditan was approved in the United States in 2019 in film-coated tablet form (Reyvow). Structure and properties Lasmiditan (C19H18F3N3O2, Mr = 377.4 g/mol) is present in the drug as lasmiditanhemisuccinate, a white crystalline powder that is sparingly soluble in water. It is a piperidine and pyridine derivative and has no indole structure. Effects Lasmiditan … Lasmiditan
Products Ganciclovir is commercially available as a lyophilizate for the preparation of an infusion solution (Cymevene). It has been approved in many countries since 1988. Furthermore, an ophthalmic gel was registered in 2020. Structure and properties Ganciclovir (C9H13N5O4, Mr = 255.2 g/mol) is present in drugs as ganciclovir sodium, a white crystalline powder that is … Ganciclovir
Products Ethosuximide is commercially available in the form of capsules (Petinimid). It has been approved in many countries since 1963. Structure and properties Ethosuximide (C7H11NO2, Mr = 141.2 g/mol) is a racemate. It exists as a white powder or waxy mass and is readily soluble in water. Indication For the treatment of minor epileptic seizures … Ethosuximide
Products Tacrolimus is commercially available for external use as an ointment in two concentrations (Protopic). It has been approved in many countries since 2001. Structure and properties Tacrolimus (C44H69NO12 – H2O, Mr = 822.0 g/mol) is a complex macrolide formed by the fungus-like bacterium. It is present in drugs as tacrolimus monohydrate, white crystals, or … Topical Tacrolimus
Products Argatroban is commercially available as a concentrate for the preparation of an infusion solution (Argatra). It was approved in many countries in 2014. Structure and properties Argatroban (C23H36N6O5S, Mr = 508.6 g/mol) is a derivative of the amino acid arginine. Effects Argatroban (ATC B01AE03) has antithrombotic properties. It inhibits fibrin formation, coagulation factor activation, … Argatroban
