Products Rivaroxaban is commercially available in the form of film-coated tablets (Xarelto, Xarelto vascular). It was approved in 2008 as the first agent in the direct factor Xa inhibitor group. Low-dose Xarelto vascular, 2.5 mg, was registered in many countries in 2019. Structure and properties Rivaroxaban (C19H18ClN3O5S, Mr = 435.9 g/mol) is a pure -enantiomer … Rivaroxaban
Products Butcher’s broom is available in pharmacies and drugstores as a gel (e.g., Alpinamed Ruscovarin), in capsule form, and as a medicinal drug. Stem plant Butcher’s broom L. belongs to the asparagus family (Asparagaceae). Medicinal drug Butcher’s broom (Rusci aculeati rhizoma) is used as medicinal raw material, the dried, whole or crushed underground parts of … Butcher’s Broom
Products Polysaccharides are present as excipients and active ingredients in numerous pharmaceuticals. They play a fundamental role in foods for nutrition. Polysaccharides are also known as glycans (glycans). Structure and properties Polysaccharides are polymeric carbohydrates composed of hundreds to thousands of sugar units (monosaccharides). As few as 11 monosaccharides are referred to as polysaccharides. They … Polysaccharides
Effects Antithrombin III (ATC B01AB02) is anticoagulant: it is an endogenous substance that inhibits blood clotting. Its action is enhanced by heparins, which bind to and activate antithrombin III. Indications Substitution therapy in patients with congenital antithrombin III deficiency.
Effects Antithrombotic Anticoagulant Fibrinolytic Active ingredients Salicylates: Acetylsalicylic acid 100 mg (Aspirin Cardio). P2Y12 antagonists: Clopidogrel (Plavix, generics). Prasugrel (Efient) Ticagrelor (Brilique) GP IIb/IIIa antagonists: Abciximab (ReoPro) Eptifibatide (Integrilin) Tirofiban (Aggrastat) PAR-1 antagonists: Vorapaxar (Zontivity) Vitamin K antagonists (coumarins): Phenprocoumon (Marcoumar). Acenocoumarol (Sintrom) Not on sale in many countries: dicoumarol, warfarin. Heparins: Heparin sodium Heparin-Calcium … Antithrombotics
Products Low-molecular-weight heparins are commercially available as injectable solutions, in the form of prefilled syringes, ampoules, and lancing ampoules. The active ingredients now commonly used in many countries were first approved in the late 1980s. Biosimilars are available in some countries. The active ingredients are abbreviated in English with the acronym LMWH (low molecular weight … Low-Molecular-Weight Heparins
Symptoms Possible symptoms of a bruise (technical term: hematoma) include swelling, pain, inflammation, and discoloration of the skin that changes (red, blue, purple, green, yellow, brown) during the healing process. This text refers to simple and small-surface complaints that can be considered for self-medication. Causes The cause of a hematoma is blood leaking from injured … Bruise (Hematoma) Symptoms and Causes
Products Fondaparinux is commercially available as a solution for injection (Arixtra). It has been approved in many countries since 2002. Structure and properties Fondaparinux (C31H43N3Na10O49S8, Mr = 1728 g/mol) is a synthetic pentasaccharide belonging to the class of glycosaminoglycans. It is present in the drug as fondaparinux sodium. Effects Fondaparinux (ATC B01AX05) has antithrombotic properties. … Fondaparinux
Products Hemeran was approved in many countries since 1962 as a cream and later as a gel and emulgel (Geigy, Novartis, GSK). It was discontinued in 2018. Ingredients Hemeran contained the heparinoid “Heparinoidum Geigy” (polygalacturonic acid). Effects Heparinoidum Geigy has anticoagulant and anti-inflammatory properties. Indications Complaints associated with varicose veins such as pain, heaviness, swollen … Hemeran
Products Heparin–Calcium is commercially available as an injectable (Calciparine). It has been approved in many countries since 1973. Structure and properties Heparin calcium is the calcium salt of a sulfated glycosaminoglycan found in mammalian tissues. It is derived from the intestinal mucosa of pigs. Heparin calcium exists as a white powder that is readily soluble … Heparin-Calcium
Products Heparin sodium is applied primarily as a gel or ointment (eg, HepaGel, Lioton, Demovarin, combination products). This article refers to topical therapy. Heparin sodium is also injected parenterally. Structure and properties Heparin sodium is the sodium salt of a sulfated glycosaminoglycan found in mammalian tissues. It is obtained from the intestinal mucosa of pigs, … Heparin Sodium
Products Dalteparin is commercially available as an injectable (Fragmin). It has been approved in many countries since 1988. Structure and properties Dalteparin is present in drugs as dalteparin sodium, the sodium salt of a low-molecular-weight heparin obtained by depolymerization of heparin from porcine intestinal mucosa using nitrous acid. The average molecular weight is 6000 Da. … Dalteparin
