Night Work

Background According to the Labor Law, shift work refers to employees working staggered and alternately at the same workplace: “Shift work occurs when two or more groups of employees are assigned to work staggered and alternately at the same workplace according to a specific schedule.” This definition also refers to work during the day. From … Night Work

Melatonin Receptor Agonists

Products Melatonin receptor agonists are commercially available in tablet and capsule form. Structure and properties Melatonin receptor agonists are structurally derived from and related to the natural hormone melatonin. Effects Melatonin, a sleep hormone produced by the pineal (pineal) gland of the brain from tryptophan, has a central role in the body in regulating the … Melatonin Receptor Agonists

Agomelatine

Products Agomelatine is commercially available in the form of film-coated tablets (Valdoxan, generic). It was approved in the EU in 2009 and in many countries in 2010. Structure and properties Agomelatine (C15H17NO2, Mr = 243.30 g/mol) exists as a white powder that is practically insoluble in water. It is a naphthalene analog of the epiphyseal … Agomelatine

Jet Lag

Symptoms Possible symptoms of jet lag include: Sleep disturbances: drowsiness and fatigue during the day, insomnia at night. Digestive disorders Malaise, feeling sick Irritability, emotional upsets Concentration disorders Causes The cause of jet lag is a desynchronization of the sleep-wake rhythm during rapid travel across multiple time zones, typically by airplane. The time at the … Jet Lag

Tasimelteon

Products Tasimelteon was approved in the United States in 2014 and in the EU in 2015 in capsule form (Hetlioz). The drug is not currently registered in many countries. Structure and properties Tasimelteon (C15H19NO2, Mr = 245.3 g/mol) exists as a white crystalline powder that is sparingly soluble in water. It is structurally related to … Tasimelteon

Ramelteon

Products Ramelteon has been approved in the United States since 2005 in the form of film-coated tablets (Rozerem). The drug is not currently registered in many countries. The EMA had rejected approval in the EU because it judged the evidence of efficacy to be insufficient. Structure and properties Ramelteon (C16H21NO2, Mr = 259.3 g/mol) exists … Ramelteon

The Best Tips against Jet Lag

Jet lag refers to a phenomenon that can occur when crossing multiple time zones. The time difference upsets the sleep-wake rhythm and other biorhythms, which can lead to symptoms such as severe fatigue and sleep disturbances. However, with a few tips and tricks, you can prevent jet lag or at least mitigate the symptoms. Also, … The Best Tips against Jet Lag

Sleep Disorders

Symptoms Sleep disorder refers to an undesirable change in the usual sleep rhythm. This manifests itself in difficulty falling asleep or staying asleep, insomnia, a change in sleep profile, sleep length, or inadequate rest. Sufferers are unable to fall asleep for long periods in the evening, wake up at night or early in the morning, … Sleep Disorders