mesalazine

Mesalazine: Effects, Uses, Side Effects

How mesalazine works Like acetylsalicylic acid, mesalazine inhibits various enzymes that produce pro-inflammatory tissue hormones (prostaglandins, leukotrienes, thromboxanes, etc.). In this way, acute inflammatory reactions (“relapses”), as they occur in chronic inflammatory bowel diseases (such as Crohn’s disease, ulcerative colitis), can often be attenuated or completely suppressed. In addition, mesalazine can neutralize reactive oxygen species … Mesalazine: Effects, Uses, Side Effects

Sulfasalazine: Drug Effects, Side Effects, Dosage and Uses

Products Sulfasalazine is commercially available as tablets and as dragées with an enteric coating (salazopyrin, salazopyrin EN, some countries: azulfidine, azulfidine EN, or RA). It has been approved in many countries since 1950. EN stands for enteric coated and RA for Rheumatoid Arthritis. EN dragées have a coating to prevent irritation and improve gastric tolerance. … Sulfasalazine: Drug Effects, Side Effects, Dosage and Uses

Suppositories (Suppositories)

Products Many drugs are available in the form of suppositories. The most commonly administered in the office are acetaminophen suppositories for the treatment of fever and pain in infants and children (photo, click to enlarge). Definition Suppositories are single-dose medicinal preparations with a solid consistency. They usually have an elongated, torpedo-like shape and a smooth … Suppositories (Suppositories)

Foams

Products Foams are commercially available as pharmaceuticals, cosmetics (personal care products), medical devices, and foods. Some examples are listed below: Rectal foam containing budesonide or mesalazine for inflammatory bowel disease (ulcerative colitis of the rectum). Glucocorticoids and calcipotriol in psoriasis of the skin or scalp. Minoxidil for the treatment of androgenetic hair loss. No drugs: … Foams

Olsalazine

Products Medicines containing olsalazine are currently no longer on the market in many countries. Dipentum (capsules, tablets) is no longer available. Structure and properties Olsalazine (C14H10N2O6, Mr = 302.2 g/mol) exists as a yellow, fine, crystalline powder that is sparingly soluble in water. Effects Olsalazine (ATC A07EC03) has anti-inflammatory properties. It is a prodrug. Olsalazine … Olsalazine

Hemorrhoids Causes and Treatment

Symptoms Hemorrhoids are dilations of the vascular cushions in the anal canal. Possible symptoms include: Bleeding, blood on the toilet paper Pressure discomfort, pain, burning, itching. Unpleasant feeling Inflammation, swelling, skin inflammation. Discharge of mucus, oozing Prolapse, protrusion outside the anus (prolapse). Hemorrhoids can be classified according to various criteria. Common is the classification according … Hemorrhoids Causes and Treatment

Mesalazine

Products Mesalazine is commercially available as film-coated tablets, enteric-coated sustained-release tablets, granules, sustained-release granules, clysms, and suppositories (e.g., Asacol, Mezavant, Pentasa, Salofalk). It has been approved in many countries since 1984. Structure and properties Mesalazine (C7H7NO3, Mr = 153.1 g/mol) corresponds to 5-aminosalicylic acid (5-ASA). The active ingredient exists as powders or crystals that are … Mesalazine

Mesalazine (5-ASA)

Introduction – What is Mesalazine? Mesalazine (trade name Salofalk®) is an active ingredient from the group of so-called aminosalicylates. It has an anti-inflammatory effect and is used to treat chronic inflammatory bowel diseases. Mesalazine is the gold standard, particularly in ulcerative colitis, but it is also used in Crohn’s disease. Mesalazine is used in acute … Mesalazine (5-ASA)

Dosage forms of Mesalazine | Mesalazine (5-ASA)

Dosage forms of Mesalazine Mesalazine in the form of suppositories is used especially when the inflammation affects the late sections of the intestine, i.e. rectum and rectum. The suppositories, as suppositories are also called, are usually inserted rectally three times a day, in acute treatment suppositories with 500mg active substance, in prophylaxis 250mg. Mesalazine suppositories … Dosage forms of Mesalazine | Mesalazine (5-ASA)

Interaction with other drugs | Mesalazine (5-ASA)

Interaction with other drugs Mesalazine shows a variety of interactions with other drugs. Patients should inform their treating physician about taking mesalazine when prescribing a drug. Interactions may decrease the effectiveness or increase the risk of side effects. Mesalazine interacts with anticoagulants, which may be more potent. The risk of gastrointestinal bleeding is increased. Mesalazine … Interaction with other drugs | Mesalazine (5-ASA)

Contraindications – When should mesalazine not be given? | Mesalazine (5-ASA)

Contraindications – When should mesalazine not be given? Mesalazine must not be taken if there is a hypersensitivity to salicylic acid and its derivatives (this includes aspirin). Contraindications for the use of mesalazine are severe liver and kidney dysfunctions. Because of the increased risk of bleeding, mesalazine must not be used in existing stomach and … Contraindications – When should mesalazine not be given? | Mesalazine (5-ASA)

Alternatives to Mesalazine | Mesalazine (5-ASA)

Alternatives to Mesalazine In the acute phase of ulcerative colitis, mesalazine is the first choice. Patients with Crohn’s disease also show a good response to the anti-inflammatory agent. In particularly severe cases, the physician may prescribe additional cortisone at times. If there is no response to the therapy, immunosuppressive drugs are used to inhibit the … Alternatives to Mesalazine | Mesalazine (5-ASA)