Products Acarbose is commercially available in tablet form (Glucobay). It is usually combined with other agents such as metformin, insulin, or sulfonylureas to enhance the antidiabetic effect. Acarbose has been approved in many countries since 1986. Structure and properties Acarbose (C25H43NO18, Mr = 645.60 g/mol) is a pseudotetrasaccharide obtained from the bacterium by fermentation. It … Acarbose Effects and Side Effects
Active ingredients Insulins substitute for endogenous insulin: Human insulin Insulin analogues Biguanides reduce hepatic glucose formation: Metformin (Glucophage, generic). Sulfonylureas promote insulin secretion from beta cells: Glibenclamide (Daonil, generic). Glibornuride (Glutril, off label). Gliclazide (Diamicron, generic). Glimepiride (Amaryl, generics) Glinides promote insulin secretion from beta cells: Repaglinide (NovoNorm, generic). Nateglinide (Starlix) Glitazones decrease peripheral insulin … Antidiabetics
Products Pancreatin is commercially available in the form of capsules, dragées, and tablets (Combizym, Creon, Panzytrat). Structure and properties Pancreatin (pancreatic powder) is obtained from the fresh or frozen pancreas of mammals, such as pigs or cattle. The substance contains digestive enzymes with proteolytic, lipolytic and amylolytic activity. Pancreatin is a faint brown, amorphous powder … Pancreatin
Products Miglitol was commercially available in tablet form (Diastabol). It was approved in many countries in 1997 and went out of commerce in 2011. It is still available in some countries. Acarbose (Glucobay) can be used as a possible alternative. Structure and properties Miglitol (C8H17NO5, Mr = 207.2 g/mol) is an analog of glucose and … Miglitol
Effects Alpha-glucosidase inhibitors (ATC A10BF) have antidiabetic properties: Glucose is released more slowly in the gut and absorbed more slowly into the blood Decrease the rise in blood glucose after meals and blood sugar fluctuations. Do not cause hypoglycemia as monotherapy Mechanism of action The action is based on the inhibition of intestinal enzymes (alpha-glucosidases) … Alpha-Glucosidase Inhibitors
What are alpha-glucosidase inhibitors and how do they work? The active ingredients from the group of substances known as alpha-glucosidase inhibitors inhibit enzymes in the intestine that break down carbohydrates absorbed with food into glucose. As a result, blood sugar rises only slowly after eating. However, alpha-glucosidase inhibitors have no effect when consuming foods with … Alpha-glucosidase inhibitor
Contraindications If you already suffer from an intestinal disease such as Crohn’s disease, ulcerative colitis, alpha-glucosidase inhibitors should not be taken in order to avoid further strain on the intestinal structures. Since the increased gas formation in the intestine also increases the general pressure in the abdomen, alpha-glucosidase inhibitors should not be taken in the … Contraindications | Alpha-glucosidase inhibitor
Intake during pregnancy and lactation Pregnant women and nursing mothers are not advised to take alpha-glucosidase inhibitors. Children and adolescents under the age of 18 should also avoid them. Unfortunately, there is too little or hardly any experience available as to how alpha-glucosidase inhibitors affect the development of the human body. Furthermore, alpha-glucosidase inhibitors should … Intake during pregnancy and lactation | Alpha-glucosidase inhibitor