Products Bromocriptine is commercially available in tablet form (Parlodel). It was developed at Sandoz in the 1960s and has been approved in many countries since 1975. Generic versions are now available in many countries. Structure and properties Bromocriptine (C32H40BrN5O5, Mr = 654.6 g/mol) is a brominated derivative of the natural ergot alkaloid ergocryptine. It is … Bromocriptine
Introduction Only in a few cases is it possible to treat the cause of dementia. Nevertheless, the use of medication can help many patients. They are used to improve the dementia patient’s mental performance and make it easier for him or her to cope with everyday life. Behavioural disorders can also be alleviated by medication. … Drugs for dementia
Drugs for vascular dementia Vascular dementia is a generic term for dementias that occur due to damage to the brain vessels. Therefore, the basis of therapy for this form of dementia is to prevent further vascular damage. This requires the adequate treatment of high blood pressure, sufficient exercise, giving up nicotine consumption and, if necessary, … Drugs for vascular dementia | Drugs for dementia
Products Uprima sublingual tablets (2 mg, 3 mg) for erectile dysfunction are no longer marketed in many countries. The marketing authorization was not renewed by Abbott AG in 2006. Commercial reasons were cited, probably attributed to competition from phosphodiesterase-5 inhibitors (e.g., sildenafil, Viagra). It is also possible that a post-marketing study had played a role, … Apomorphine
Effects Indirect dopaminergic Indications Parkinson’s disease Depression (USA) Active ingredients Rasagiline (Azilect) Selegiline (off label) Safinamide (Xadago)
Products Paliperidone is commercially available as sustained-release tablets (Invega, generic) and as a sustained-release suspension for intramuscular injection (Xeplion, Trevicta, generic). It has been approved in many countries since 2008. Structure and properties Paliperidone (C23H27FN4O3, Mr = 426.5 g/mol) exists as a racemate and is practically insoluble in water. It belongs to the group of … Paliperidone
Definition A Parkinson’s syndrome is a clinical picture with typical symptoms that restrict movement. These symptoms are immobility (akinesia) or slowed movement, muscle rigidity (rigor), muscle tremor (rest tremor) and postural instability (postural instability). The symptoms are caused by a lack of dopamine, a neurotransmitter that controls movement in the brain. The symptoms do not … Parkinson’s syndrome
These stadiums exist There are three phases of Parkinson’s disease. The first is the preclinical phase, in which no symptoms are present. This phase is currently being researched to find clues for early detection of Parkinson’s disease. The so-called prodromal stage follows and can last from years to decades. This is when the early symptoms … These stadiums exist | Parkinson’s syndrome
Life expectancy with a Parkinson’s syndrome Patients with Parkinson’s disease can have a normal life expectancy with good therapy! In the first ten years, the first fluctuations in the effect of the drugs occur. Within about 20 years of the disease, most of those affected are in need of care. In most cases, the causes … Life expectancy with a Parkinson’s syndrome | Parkinson’s syndrome
Products Rotigotine is commercially available as a transdermal patch in various potencies (Neupro). It was approved in many countries in 2006 as the first TTS for Parkinson’s disease therapy. Structure and properties Rotigotine (C19H25NOS, Mr = 315.5 g/mol) is an aminotetralin and thiophene derivative structurally related to dopamine. It has a non-ergoline structure and exists … Rotigotine
Products Pergolide (Permax) had been approved in tablet form in many countries since 1997. On Sept. 30, 2011, Permax went off the market in many countries. The reason given for the market withdrawal was a fire at the packaging plant. Other dopamine agonists are available as alternatives. Structure and properties Pergolide (C19H26N2S, Mr = 314.5 … Pergolide
Products Ropinirole is commercially available in the form of film-coated tablets (Adartrel, Requip, generic). It has been approved in many countries since 1996. Structure and properties Ropinirole (C16H24N2O, Mr = 260.4 g/mol) is a non-ergoline dopamine agonist and a dihydroindolone derivative. It is present in drugs as ropinirole hydrochloride, a white to yellow powder that … Ropinirole
