Products Prednicarbate is commercially available as a cream, solution, and ointment (Prednitop, Prednicutan). It has been approved in many countries since 1990. Structure and properties Prednicarbate (C27H36O8, Mr = 488.6 g/mol) belongs to the class of potent glucocorticoids (class III). It is a non-halogenated prednisolone derivative. It exists as an odorless, white to yellowish-white, crystalline … Prednicarbate
Products To date, hydrocortisone acetate is the only glucocorticoid approved for self-medication in many countries and is available without a doctor’s prescription. A cream (Dermacalm with dexpanthenol) and a hydrocream (Sanadermil) are available. Hydrocortisone was the first dermocorticoid and was introduced in the 1950s. Structure and properties Hydrocortisone acetate (C23H32O6, Mr = 404.5 g/mol) is … Hydrocortisone Acetate
Products Hydrocortisone butyrate is commercially available as emulsion and cream (Locoid). It has been approved in many countries since 1973. Structure and properties Hydrocortisone-17-butyrate (C25H36O6, Mr = 432.6 g/mol) is an esterified, nonhalogenated glucocorticoid. It is a derivative of endogenous hydrocortisone. Effects Hydrocortisone butyrate (ATC D07AB02) has anti-inflammatory, antiallergic, immunosuppressive, and antipruritic properties. The effects … Hydrocortisone Butyrate
Products Cortisone mixed ointments are not commercially available as finished drug products. They are prepared in pharmacies as extemporaneous preparations. Usually, a cream or ointment containing cortisone is diluted by mixing it with an ingredient-free base, such as Excipial or Antidry. The concentration of the glucocorticoid decreases in the process. However, the risk for adverse … Cortisone Mixed Ointments
Products Methylprednisolone aceponate has been approved in many countries since 1991 and is commercially available as cream, ointment, and fatty ointment (Advantan). Structure and properties Methylprednisolone aceponate (C27H36O7, Mr = 472.6 g/mol) is a lipophilic and nonhalogenated glucocorticoid that is hydrolyzed in the skin by esterases to the active metabolite 6α-methylprednisolone-17-propionate. Effects Methylprednisolone aceponate (ATC … Methylprednisolone Aceponate
Products Halcinonide was commercially available as a solution, cream, and fat cream, and was also combined fixedly with urea and salicylic acid (Betacorton, Betacorton S). It was approved in many countries in 1981. It was discontinued from 2018 to 2019. Structure and properties Halcinonide (C24H32ClFO5, Mr = 454.96 g/mol) exists as a white powder that … Halcinonide
Products Halometasone is commercially available as a cream in combination with triclosan (Sicorten plus). It has been approved in many countries since 1983. Structure and properties Halometasone (C22H27ClF2O5, Mr = 444.9 g/mol) is a chlorinated and fluorinated (halogenated) steroid. Effects Halometasone (ATC D07AC12) has anti-inflammatory, antiallergic, and immunosuppressive properties. It is a potent class III … Halometasone
Products Tretinoin is commercially available as a cream and lotion (Airol) and in capsule form (Vesanoid). It has been approved in many countries since 1973. The Retin-A cream and gel went out of commerce in many countries at the end of 2012 for commercial reasons. This article refers to external treatment. Structure and properties Tretinoin … Tretinoin
Products Mometasone furoate is commercially available as a cream, ointment, emulsion, and solution (Elocom, Monovo, Ovixan). It has been approved in many countries since 1989. This article refers to use on the skin. Nasal sprays are also available; see mometasone nasal spray. In 2020, a fixed combination with indacaterol was approved for asthma therapy (Atectura … Mometasone
Products Fluprednidene acetate is commercially available as a cream in many countries and has been approved since 1993 (Decoderm bivalent + miconazole nitrate). Structure and properties Fluprednidene acetate (C24H29FO6, Mr = 432.5 g/mol) Effects Fluprednidene acetate (ATC D07AB07) has anti-inflammatory, antiallergic, antipruritic, and antiproliferative properties. The effects are due to binding to intracellular glucocorticoid receptors. … Fluprednidene Acetate
Products Fluocinolone acetonide is commercially available as an ointment, cream, and suppositories (Synalar, Procto-Synalar N). It has been approved in many countries since 1963. Structure and properties Fluocinolone acetonide (C24H30F2O6, Mr = 452.5 g/mol) exists as a white crystalline powder that is practically insoluble in water. It is a fluorinated and fused glucocorticoid. Effects Fluocinolone … Fluocinolone Acetonide
Products Fluocinonide is commercially available as a cream and ointment in mono and combination formulations (Topsym). It has been approved in many countries since 1971. Structure and properties Fluocinonide (C26H32F2O7, Mr = 494.5 g/mol) is a fluorinated glucocorticoid. Effects Fluocinonide (ATC D07AC08) has anti-inflammatory, antiallergic, antipruritic, and immunosuppressive properties. The effects are due to binding … Fluocinonide
