Products Proguanil is commercially available in the form of film-coated tablets and exclusively as a fixed combination with atovaquone (Malarone, generic). It has been approved in many countries since 1997. Generics went on sale in 2013. Structure and properties Proguanil (C11H16ClN5, Mr = 253.7 g/mol) is an active ingredient of the biguanide group. It exists … Proguanil
Products Atovaquone is commercially available in suspension and film-coated tablet form (Wellvone, Malarone + Proguanil, generics). It has been approved in many countries since 1996. Structure and properties Atovaquone (C22H19ClO3, Mr = 366.8 g/mol) is a hydroxynaphtoquinone derivative and has structural similarities to ubiquinone. It is lipophilic and exists as a yellow crystalline powder that … Atovaquon
Symptoms Malaria (Italian, “bad air”) manifests itself in the following symptoms, which usually appear a few weeks after transmission. The incubation period ranges from a few days to several years: High fever, sometimes with rhythmic attacks of fever, every second or third day. However, the fever may also occur irregularly. Chills, profuse sweating. Headache, muscle … Malaria Causes and Treatment
Effects Antiparasitic against plasmodia. Indications Malaria Malaria prophylaxis Also for the treatment of rheumatic diseases, lupus erythematosus. Off-label: some antimalarials such as quinine and chloroquine are used off-label to treat calf cramps. Active ingredients Aminoquinolines: Amodiaquine Chloroquine (Nivaquine, out of commerce). Hydroxychloroquine (Plaquenil) Mepacrine Pamaquin Piperaquine Primaquine Tafenoquin (crinoline) Biguanides: Proguanil (Malarone + Atovaquone). Cycloguanilembonate … Antimalarials
