Products Sulfadiazine is commercially available in combination with silver as silver sulfadiazine cream and gauze (Flammazine, Ialugen plus). This article refers to internal use. See also under silver sulfadiazine. Structure and properties Sulfadiazine (C10H10N4O2S, Mr =250.3 g/mol) exists as in the form of crystals or as a crystalline powder with white, yellowish or light pink … Sulfadiazine
Effect Antibacterial Bakeriostatic Antiparasitic against protozoa Mechanism of action Sulfonamides inhibit the synthesis of folic acid in microorganisms. They are structural analogues (antimetabolites) of the natural substrate p-aminobenzoic acid and competitively displace it. Trimethoprim, used in combination with sulfamethoxazole, has a synergistic effect. Indications Bacterial infectious diseases caused by: Streptococcus Pneumococcus Actinomycetes Nocardia, e.g. nocaridosis … Sulfonamides
Products Dapsone is approved in Germany in tablet form (Dapsone-Fatol). In the USA, it is additionally on the market as a gel for the treatment of acne (Aczone). No preparations are currently registered in many countries. Structure and properties Dapsone or 4,4′-diaminodiphenylsulfone (C12H12N2O2S, Mr = 248.3 g/mol) is a sulfone and aniline derivative with structural … Dapsone
Symptoms Toxoplasmosis is usually asymptomatic and unnoticed if the immune status is normal. It may manifest as flu-like symptoms such as muscle and joint pain, sore throat, swollen lymph nodes, headache, fever, and fatigue. The infection leads to immunity. If the immune system is weakened, such as observed in HIV infection and when taking immunosuppressants … Toxoplasmosis Causes and Treatment
Products Trimethoprim and sulfamethoxazole are commercially available in tablet and syrup form (Bactrim, generics). The drug has been approved in many countries since 1969. The Bactrim syrup is no longer available, but a generic is available (Nopil syrup). The fixed combination of the two active ingredients is also called cotrimoxazole. Structure and properties Trimethoprim (C14H18N4O3, … Trimethoprim and Sulfamethoxazole
Products Quinine is approved in many countries in the form of dragées for malaria therapy (quinine sulfate 250 Hänseler). In Germany, film-coated tablets of 200 mg quinine sulfate are commercially available for the treatment of calf cramps (Limptar N). Structure and properties Quinine (C20H24N2O2, Mr = 324.4 g/mol) usually exists as quinine sulfate, a white … Quinine
Products Pyrimethamine is commercially available in tablet form (Daraprim). The combination Fansidar (+ sulfadoxine) is off the market (malaria). Structure and properties Pyrimethamine (C12H13ClN4, Mr = 248.7 g/mol) is a diaminopyrimidine. It exists as a white crystalline powder or as colorless crystals and is practically insoluble in water. Effects Pyrimethamine (ATC P01BD01) has antiparasitic properties. … Pyrimethamine
Effects Antiparasitic against plasmodia. Indications Malaria Malaria prophylaxis Also for the treatment of rheumatic diseases, lupus erythematosus. Off-label: some antimalarials such as quinine and chloroquine are used off-label to treat calf cramps. Active ingredients Aminoquinolines: Amodiaquine Chloroquine (Nivaquine, out of commerce). Hydroxychloroquine (Plaquenil) Mepacrine Pamaquin Piperaquine Primaquine Tafenoquin (crinoline) Biguanides: Proguanil (Malarone + Atovaquone). Cycloguanilembonate … Antimalarials
The active ingredient pyrimethamine is a so-called antiparasitic drug. Pyrimethamine belongs to the category of antiparasitics and is primarily used for the prophylaxis of malaria as well as for the treatment of toxoplasmosis. The substance pyrimethamine is a derivative of diaminopyrimidine and, in combination with other agents, is suitable for the prevention of pneumonia caused … Pyrimethamine: Effects, Uses & Risks
