Products Minoxidil is commercially available as a solution and in some countries also as a foam (Regaine, generics, USA: Rogaine). It has been approved in many countries since 1987. The brand name plays on the English verb , which translates as to recover or get back. This article refers to external use. Tablets also exist … Minoxidil
Products The fixed combination of netupitant and palonosetron has been approved in capsule form (Akynzeo). The drug was released in many countries in 2015. Structure and properties Netupitant (C30H32F6N4O, Mr = 578.6 g/mol) is a fluorinated piperazine and pyrimidine derivative. Palonosetron (C19H24N2O, Mr = 296.4 g/mol) is present in drugs as palonosetron hydrochloride, a white … Netupitant, Palonosetron
Products Trametinib was approved in the form of film-coated tablets in the United States in 2013, in the EU in 2014, and in many countries in 2016 (Mekinist). Structure and properties Trametinib (C26H23FIN5O4, Mr = 615.4 g/mol) is a pyridine and a pyrimidine derivative. It is present in the drug product as trametinib dimethyl sulfoxide, … Trametinib
Products Buspirone was available in many countries in tablet form (Buspar). It was approved in 1986 and went off the market in 2010. Structure and properties Buspirone (C21H31N5O2, Mr = 385.5 g/mol) is an azapirone, a piperazine and pyrimidine derivative. It is present in drugs as buspirone hydrochloride, a white crystalline powder that is soluble … Buspiron
Products Macitentan is commercially available in the form of film-coated tablets (Opsumit). It was approved in the United States in October 2013 and in many countries in 2014. Macitentan was launched as a successor to bosentan (Tracleer) as it loses patent protection. Structure and properties Macitentan (C19H20Br2N6O4S, Mr = 588.3 g/mol) is a brominated pyrimidine … Macitentan
Products Magnesium orotate is commercially available as a monopreparation in tablet form (e.g., Burgerstein Magnesium Orotate). Structure and properties Magnesium orotate (C10H6MgN4O8, Mr = 334.5 g/mol) is the magnesium salt of orotic acid. Orotic acid is a pyrimidine derivative. Magnesium orotate is usually present in drugs as magnesium orotate dihydrate. 400 mg magnesium orotate dihydrate … Magnesium Orotate
Products Dabrafenib was approved in the US and EU in 2013 and in many countries in 2014 in hard capsule form (Tafinlar). Structure and properties Dabrafenib (C23H20F3N5O2S2, Mr = 519.6 g/mol) is present in drugs as dabrafenib mesilate, a white to slightly colored powder that is practically insoluble in water. It is a thiazole and … Dabrafenib
Products Voriconazole is commercially available as film-coated tablets, powder for the preparation of an infusion solution, and powder for the preparation of a suspension (Vfend, generics). It has been approved in many countries since 2002. Structure and properties Voriconazole (C16H14F3N5O, Mr = 349.3 g/mol) exists as a white powder that is very sparingly soluble in … Voriconazole
Products Osimertinib was approved in the United States in 2015 and in the EU and Switzerland in 2016 in film-coated tablet form (Tagrisso). Structure and properties Osimertinib exists in the drug product as osimertinib mesilate (C28H33N7O2 – CH4O3S, Mr = 596 g/mol). It is a methylindole, aniline and pyrimidine derivative. Effects Osimertinib (ATC L01XE35) has … Osimertinib
Products Oxantel is commercially available as tablets and chewable tablets in combination preparations. It has been approved in many countries since 2008 and exclusively as a veterinary drug. Structure and properties Oxantel (C13H16N2O, Mr = 216.3 g/mol) is a pyrimidine derivative derived from pyrantel. It exists as a pale yellow crystalline powder and is practically … Oxantel
Products Alogliptin is commercially available in film-coated tablet form as a monopreparation (Vipidia) and as a fixed combination with metformin (Vipdomet). It was approved in many countries in 2013. Structure and properties Alogliptin (C18H21N5O2, Mr = 339.4 g/mol) is present in drugs as alogliptin benzoate, a white crystalline powder that is sparingly soluble in water. … Alogliptin
Products Avanafil is commercially available in tablet form (Spedra, some countries: Stendra). It was approved in the US in April 2012, in the EU in 2013, and in many countries in 2016. Structure and properties Avanafil (C23H26ClN7O3, Mr = 483.95 g/mol) is a pyrimidine derivative. It exists as a white crystalline powder that is practically … Avanafil