serotonin syndrome

Serotonin Syndrome: Causes, Treatment

Brief overview Symptoms: Profuse sweating, reddened skin, dry mucous membranes, high pulse and blood pressure, nausea and vomiting, disturbances between muscles and nerves (tremors, muscle rigidity, excessive reflexes), psychological disturbances (restlessness, agitation, impaired consciousness) as well as cardiac arrhythmias, epileptic seizures and organ failure Treatment: discontinuation of causative medications, extensive cooling if fever is high, … Serotonin Syndrome: Causes, Treatment

Zolmitriptan

Products Zolmitriptan is commercially available as film-coated tablets, meltable tablets, and as a nasal spray (Zomig, generics). It has been approved in many countries since 1997. Generic versions entered the market in 2012. Structure and properties Zolmitriptan (C16H21N3O2, Mr = 287.4 g/mol) is an indole and oxazolidinone derivative structurally related to serotonin. It exists as … Zolmitriptan

Rizatriptan

Products Rizatriptan is commercially available in tablet and lingual (melting) tablet form (Maxalt, generics). It has been approved in many countries since 2000. Generic versions went on sale in 2015. Structure and properties Ritatriptan (C15H19N5, Mr = 269.3 g/mol) is present in drugs as rizatriptan benzoate, a white crystalline powder that is soluble in water. … Rizatriptan

Netupitant, Palonosetron

Products The fixed combination of netupitant and palonosetron has been approved in capsule form (Akynzeo). The drug was released in many countries in 2015. Structure and properties Netupitant (C30H32F6N4O, Mr = 578.6 g/mol) is a fluorinated piperazine and pyrimidine derivative. Palonosetron (C19H24N2O, Mr = 296.4 g/mol) is present in drugs as palonosetron hydrochloride, a white … Netupitant, Palonosetron

Paroxetine

Products Paroxetine is commercially available as film-coated tablets and as a suspension (Deroxat, generic). It has been approved in many countries since 1993. Paroxetine is also marketed as Seroxat and Paxil in some countries. Slow-release paroxetine (CR) is not currently available in many countries. Structure and properties Paroxetine (C19H20FNO3, Mr = 329.4 g/mol) is present … Paroxetine

Dextromethorphan

Products Dextromethorphan is available in the form of tablets, lozenges, sustained-release capsules, syrup, and drops, among others (in many countries, for example, Bexin, Calmerphan, Calmesin, Pulmofor, combination preparations). The first drugs came on the market in the 1950s. Structure and properties Dextromethorphan (C18H25NO, Mr = 271.4 g/mol) was developed as an analog of codeine and … Dextromethorphan

Pethidine

Products Pethidine is commercially available as a solution for injection. It has been approved in many countries since 1947. The drug is subject to strict control as a narcotic and is available only by prescription. Structure and properties Pethidine (C15H21NO2, Mr = 247.3 g/mol) is a phenylpiperidine derivative. In pharmaceuticals, it is present as pethidine … Pethidine

Tramadol: Drug Effects, Side Effects, Dosage and Uses

Products Tramadol is commercially available in the form of tablets, capsules, melting tablets, drops, effervescent tablets, suppositories, and as a solution for injection. (Tramal, generic). Fixed combinations with acetaminophen are also available (Zaldiar, generic). Tramadol was developed by Grünenthal in Germany in 1962 and has been approved in many countries since 1977 and in the … Tramadol: Drug Effects, Side Effects, Dosage and Uses

Linezolid

Products Linezolid is commercially available as an infusion solution, in the form of film-coated tablets, and as granules for preparation of a suspension (Zyvoxid, generics). It has been approved in many countries since 2001. Structure and properties Linezolid (C16H20FN3O4, Mr = 337.3 g/mol) was the first agent developed from the oxazolidinone group. It is structurally … Linezolid

Eletriptan

Products Eletriptan is commercially available in the form of film-coated tablets (Relpax, generics). It has been approved in many countries since 2000. Structure and properties Eletriptan (C22H26N2O2S, Mr = 382.5 g/mol) is a lipophilic methylpyrrolidinyltryptamine substituted with a sulfonylbenzene. It is present in drugs as eletriptan hydrobromide, a white powder that is readily soluble in … Eletriptan

Fluvoxamine

Products Fluvoxamine is commercially available in the form of film-coated tablets (Floxyfral). It has been approved in many countries since 1983. Structure and properties Fluvoxamine (C15H21F3N2O2, Mr = 318.33 g/mol) is present in drugs as fluvoxamine maleate, a white, odorless, crystalline powder that is sparingly soluble in water. Effects Fluvoxamine (ATC N06AB08) has antidepressant properties. … Fluvoxamine

Triptans: Drug Effects, Side Effects, Dosage and Uses

Products Triptans are mainly taken in the form of film-coated tablets and melting tablets. Some are also available as subcutaneous injectable solutions and nasal sprays. Suppositories are no longer commercially available in many countries. Sumatriptan (Imigran) was the first agent in this group to be approved in the United States in 1992 and in many … Triptans: Drug Effects, Side Effects, Dosage and Uses