Definition When two or more drugs are combined, they may affect each other. This is especially true with regard to their pharmacokinetics (ADME) and effects and adverse effects (pharmacodynamics). This phenomenon is called interaction and drug-drug interaction. Interactions are usually undesirable because they can lead to, for example, loss of efficacy, side effects, poisoning, hospitalization, … Interactions
Products Most antidepressants are commercially available in the form of film-coated tablets. In addition, oral solutions (drops), meltable tablets, dispersible tablets, and injectables are also available, among others. The first representatives were developed in the 1950s. It was discovered that the antituberculosis drugs isoniazid and iproniazid (Marsilid, Roche) had antidepressant properties. Both agents are MAO … Antidepressants
Products Dapoxetine is commercially available in the form of film-coated tablets (Priligy). It has been approved in many countries since 2013. Structure and properties Dapoxetine (C21H23NO, Mr = 305.4 g/mol) is present in drugs as dapoxetine hydrochloride, a white powder with a bitter taste that is soluble in water. Dapoxetine is a naphthyloxyphenylpropanamine derivative. It … Dapoxetine
Products Duloxetine is commercially available in the form of capsules (Cymbalta, generic). It has been approved in many countries since 2005. Structure and properties Duloxetine (C18H19NOS, Mr = 297.4 g/mol) is present in drugs as pure -duloxetine hydrochloride, a white to light brown powder that is sparingly soluble in water. Effects Duloxetine (ATC N06AX21) has … Duloxetine
Products In many countries, no medicines containing milnacipran are registered. In other countries, film-coated tablets and capsules are available, for example Savella in the United States. Structure and properties Milnacipran (C15H22N2O, Mr = 246.4 g/mol) is present in the drug as milnacipran hydrochloride, a white crystalline powder that is readily soluble in water. It is … Milnacipran
Products Trazodone is commercially available in the form of film-coated tablets and sustained-release tablets (Trittico, Trittico retard, Trittico Uno). The active ingredient was developed at Angelini in Italy in 1966 and has been approved in many countries since 1985. Auto-generics and generics are registered. Generic versions of the 100 mg film-coated tablets first went on … Trazodone
Products Psychotropic drugs are commercially available, for example, in the form of tablets, melting tablets, dragées, capsules, drops, solutions and as injectables. The first psychotropic drugs were developed in the 1950s. Structure and properties Psychotropic drugs vary chemically, but groups with a common structure can be identified, for example, the benzodiazepines, the phenothiazines, and the … Psychotropic Drugs: Types, Effects, Indications, Dosage
Products Venlafaxine is commercially available in tablet and sustained-release capsule form. In addition to the original Efexor ER (USA: Effexor XR), generic versions are also available. The active ingredient was approved in many countries in 1997. Structure and properties Venlafaxine (C17H27NO2, Mr= 277.4 g/mol) is a bicyclic phenylethylamine and cyclohexanol derivative that is structurally closely … Venlafaxine: Drug Effects, Side Effects, Dosage and Uses
Products Fentanyl is commercially available in many countries in the form of lozenges, buccal tablets, sublingual tablets, as a fentanyl patch (e.g., Durogesic, generic), and as a solution for injection. It is a narcotic and is subject to enhanced prescription requirements. Structure and properties Fentanyl (C22H28N2O, Mr = 336.5 g/mol) exists as a white powder … Fentanyl: Drug Effects, Side Effects, Dosage and Uses
Products Almotriptan is commercially available in the form of film-coated tablets (Almogran). It has been approved in many countries since 2004. Structure and properties Almotriptan (C17H25N3O2S, Mr = 335.5 g/mol) is present in drugs as almotriptan-D,L-hydrogenmalate, a white to slightly yellowish crystalline powder that is soluble in water. Effects Almotriptan (ATC N02CC05) has vasoconstrictive, analgesic, … Almotriptan for Migraine Headache
Products Tapentadol is approved in film-coated tablet, sustained-release tablet, and solution forms (Palexia /-retard). It was released in many countries in late February 2011 and went on sale in the fall. Tapentadol, like tramadol (Tramal, generics), was developed at Grünenthal. The sustained-release tablets were approved in 2013 and the solution went on sale in many … Tapentadol
Products Lorcaserin is commercially available in the form of film-coated tablets (Belviq). It was approved in the United States on June 27, 2012. It is not currently registered in many countries. Structure and properties Lorcaserin (C 11 H 14 ClN, M r = 195.7 g/mol) is present in drugs as lorcaserin hydrochloride and hemihydrate, a … Lorcaserin
