Products Lanadelumab was approved as an injectable in the US and EU in 2018 and in many countries in 2019 (Takhzyro). Structure and properties Lanadelumab is a recombinant human IgG1κ monoclonal antibody with a molecular mass of 146 kDa. It is produced by biotechnological methods. Effects The effects of lanadelumab (ATC B06AC05) are based on … Lanadelumab
Products Lanreotide is commercially available as a solution for injection (Somatuline Autogel). It has been approved in many countries since 2004. Structure and properties Lanreotide is present in the drug as lanreotide acetate. It is a synthetic octapeptide analog of somatostatin with the following structure: D-βNal-Cys-Tyr-D-Trp-Lys-Val-Cys-Thr-NH2, x(CH3COOH), where x = 1 to 2 Effects Lanreotide … Lanreotide
Products Sarilumab was approved in the United States and EU in 2017 and in many countries in 2018 as a solution for injection (Kevzara, prefilled syringe, prefilled pen). Structure and properties Sarilumab is a human IgG1 monoclonal antibody with a molecular mass of 150 kDa. It is produced by biotechnological methods. Effects Sarilumab (ATC L04AC14) … Sarilumab
Products Naloxone nasal spray was approved in the United States in 2015 (Narcan), in the EU in 2017, and in many countries in 2018 (Nyxoid). Each nasal spray contains only one dose and can be used only once. Structure and properties Naloxone (C19H21NO4, Mr = 327.37 g/mol) is a semisynthetic derivative of morphine. It is … Naloxone Nasal Spray
Products Naloxone is commercially available as a solution for injection (Naloxone OrPha, Naloxone Actavis) and has been approved in many countries since 2004. Information on combination with oxycodone is presented under the article Oxycodone and Naloxone (Targin, Peroral). As a fixed combination with buprenorphine, naloxone is used to treat opioid dependence (Suboxone, sublingual). In 2014, … Naloxone
Products Epinephrine is commercially available as an injection solution and as an epinephrine auto-injector from various suppliers. The active ingredient is also known as epinephrine, especially in English (in German: Epinephrin). Structure and properties Epinephrine (C9H13NO3, Mr = 183.2 g/mol) exists as a white, crystalline powder with a bitter taste that turns brownish on contact … Adrenaline
Products Afamelanotide is administered as an implant (Scenesse, Clinuvel). It has had orphan drug status in many countries since 2008. It has not yet been registered with Swissmedic and is not approved as a drug. In the United States, the drug was approved in 2019. Structure and properties Afamelanotide is an analog of α-melanocyte-stimulating hormone … Afamelanotide
Products Degarelix is commercially available as a powder and solvent for solution for injection (Firmagon). It was approved in many countries in February 2010. Structure and properties Degarelix is a decapeptide derived from gonadotropin-releasing hormone (GnRH), a hormone of the hypothalamus. It is present in drugs as degarelix acetate and differs from the natural substance … Degarelix
Products Alirocumab was approved in the United States in 2015 as the first agent in the group of PCSK9 inhibitors in the form of a solution for injection (Praluent). Evolocumab (Repatha) followed as the second agent in the EU, also in 2015. Structure and properties PCSK9 inhibitors to date are monoclonal antibodies that must be … PCSK9 Inhibitors
The hypodermis is the lowest of three layers of the skin. It is virtually the supply and support station of the entire skin with a number of other important functions. What is the hypodermis? Schematic diagram showing the anatomy and structure of the skin. The skin is a sensitive organ. Daily care and medical precautions … Subcutis: Structure, Function & Diseases
Synonyms Bruise, bruise General A bruise (haematoma) is the often visible accumulation of blood in the subcutaneous tissue (subcutis) or deeper lying skin tissue, more rarely also in a previously existing body cavity. In general, a hematoma is a sign of illness (symptom) that indicates an injury or the use of force. In rare cases, … Hematoma
Prognosis The prognosis of a hematoma is generally very good. However, if complications occur, or if the hematoma is merely the sign of another disease, the prognosis of the affected person naturally depends on the corresponding complication or the underlying disease. However, in an otherwise healthy patient, complete healing of the hematoma can usually be … Prognosis | Hematoma
