How sulfasalazine works Sulfasalazine is used as a basic treatment for rheumatic diseases and inflammatory bowel disease (IBD). Rheumatism is a group of autoimmune diseases. This means that the immune system attacks and breaks down the body’s own tissue (such as joint cartilage). Chronic inflammatory bowel diseases are also caused by a faulty reaction of … Sulfasalazine: Effects, Applications, Side Effects
Products Sulfasalazine is commercially available as tablets and as dragées with an enteric coating (salazopyrin, salazopyrin EN, some countries: azulfidine, azulfidine EN, or RA). It has been approved in many countries since 1950. EN stands for enteric coated and RA for Rheumatoid Arthritis. EN dragées have a coating to prevent irritation and improve gastric tolerance. … Sulfasalazine: Drug Effects, Side Effects, Dosage and Uses
Effect Antibacterial Bakeriostatic Antiparasitic against protozoa Mechanism of action Sulfonamides inhibit the synthesis of folic acid in microorganisms. They are structural analogues (antimetabolites) of the natural substrate p-aminobenzoic acid and competitively displace it. Trimethoprim, used in combination with sulfamethoxazole, has a synergistic effect. Indications Bacterial infectious diseases caused by: Streptococcus Pneumococcus Actinomycetes Nocardia, e.g. nocaridosis … Sulfonamides
Symptoms Rheumatoid arthritis is a chronic, inflammatory and systemic joint disease. It manifests as pain, symmetrically tense, achy, warm, and swollen joints, swelling, and morning stiffness that lasts for more than an hour. Initially, the hands, wrists, and feet are most affected, but later numerous other joints are also affected. Over time, deformities and rheumatoid … Rheumatoid Arthritis Causes and Treatment
Products Etanercept is commercially available as a solution for injection (Enbrel, biosimilars). It has been approved in many countries since 2000. The biosimilars Benepali and Erlezi were approved in many countries in 2018. Structure and properties Etanercept is a dimeric fusion protein composed of the extracellular ligand-binding domain of TNF receptor-2 and the Fc domain … Etanercept
Products Mesalazine is commercially available as film-coated tablets, enteric-coated sustained-release tablets, granules, sustained-release granules, clysms, and suppositories (e.g., Asacol, Mezavant, Pentasa, Salofalk). It has been approved in many countries since 1984. Structure and properties Mesalazine (C7H7NO3, Mr = 153.1 g/mol) corresponds to 5-aminosalicylic acid (5-ASA). The active ingredient exists as powders or crystals that are … Mesalazine
Symptoms Typical symptoms of agranulocytosis include fever, chills, feeling ill, tonsillitis, sore throat, difficulty swallowing, and lesions and bleeding of the oral, nasal, pharyngeal, genital, or anal mucosa. The disease can lead to dangerous infections and blood poisoning and, if left untreated, can relatively often be fatal. Agranulocytosis usually occurs rarely to very rarely as … Agranulocytosis Symptoms and Treatment
What are prodrugs? Not all active pharmaceutical ingredients are directly active. Some must first be converted to the active substance by an enzymatic or non-enzymatic conversion step in the body. These are the so-called . The term was introduced by Adrien Albert in 1958. It is estimated that up to 10% of all active ingredients … Prodrugs
Symptoms A change in urine color is manifested by a deviation from the normal color of urine, which usually varies from pale yellow to amber. It may occur as a solitary sign or along with other symptoms. Urine is usually clear and not cloudy. It gets its color from urine pigments called urochromes. These are, … Change in Urine Color
Introduction Crohn’s disease is a so-called chronic inflammatory bowel disease, or CED for short. It progresses in relapses and is not curable. For this reason, patients are usually forced to take medication throughout their lives to prevent new relapses (remission maintenance). Whereas a few decades ago cortisone was the only known drug for the treatment … Medicines for Crohn’s disease
Cortisone therapy Cortisone is used in Crohn’s disease primarily for the treatment of acute relapses. It can be administered systemically as a tablet or in some cases locally as an enema or klysma. In mild to moderate attacks, cortisone preparations almost always lead to an improvement in symptoms. Even the most severe relapses can be … Cortisone therapy | Medicines for Crohn’s disease
Biologics Biologics (also known as biologicals or biopharmaceuticals) are drugs that are very similar or similar to the body’s own proteins. In the case of Crohn’s disease, for example, antibodies are used that attack very specific cells or even just molecules of the body and thus fight inflammation. Adalimumab and Infliximab, both of which are … Biologics | Medicines for Crohn’s disease