Favipiravir

Products Favipiravir is approved in Japan in the form of film-coated tablets (Avigan). Structure and properties Favipiravir (C5H4FN3O2, Mr = 157.1 g/mol) is a fluorinated pyrazine carboxamide derivative. It is a prodrug that is biotransformed in cells to the active metabolite favipiravir-RTP (favipiravir-ribofuranosyl-5′-triphosphate), a purine nucleotide analog. Favipiravir exists as a white to slightly yellow … Favipiravir

Isotretinoin

Products Isotretinoin is commercially available in capsule and gel form (Roaccutane, generics). It has been approved in many countries since 1983 (United States: 1982, Accutane). This article refers to the capsules. See also under isotretinoin gel. Structure and properties Isotretinoin (C20H28O2, Mr = 300.4 g/mol) exists as a yellow to light orange crystalline powder that … Isotretinoin

Divisibility of Tablets

Flexible dosage By dividing, the fixed dose of tablets can be changed, which increases flexibility. This is because a dose reduction may be necessary for children, for patients with renal insufficiency, for drug interactions, or for altered drug metabolism. Tablets are also divided for economic reasons. For example, the duration of therapy may be doubled … Divisibility of Tablets

Telavancin

Products Telavancin is commercially available as a powder for the preparation of a concentrate for infusion solution (Vibativ). It was approved in the EU in 2011. Structure and properties Telavancin (C80H106Cl2N11O27P, Mr = 1755.6 g/mol) is a complex molecule and a semisynthetic derivative of vancomycin. It was supplemented with, among other things, a lipophilic decylaminoethyl … Telavancin

Vitamin A

Products Vitamin A is commercially available in the form of pharmaceuticals, dietary supplements, foods, and cosmetics, among others. Dosage forms include, for example, capsules, tablets, effervescent tablets, syrups and eye ointments. Structure and properties Vitamin A is one of the fat-soluble vitamins and is practically insoluble in water. Vitamin A is the name given to … Vitamin A

DEET

Products DEET is most commonly used in the form of a spray, but is also sold in other dosage forms. Among the best-known products in many countries is Anti Brumm forte. Some products are combined with other repellents. DEET was developed by the United States Department of Agriculture for the military in the 1940s and … DEET

Progesterone Receptor Ligands

Definition The group of progesterone receptor ligands includes pure agonists, such as progesterone, pure antagonists, and selective progesterone receptor modulators (SPRMs) with agonistic and antagonistic potential. Effects Progesterone antagonism or progesterone agonism, depending on the substance and tissue. Mechanism of action Binding to the progesterone receptor. Indications and potential indications To date, only mifepristone has … Progesterone Receptor Ligands

Vismodegib

Products Vismodegib is commercially available in capsule form (Erivedge). The drug was newly approved in many countries in May 2013. Structure and properties Vismodegib (C19H14Cl2N2O3S, Mr = 421.3 g/mol) is a chlorinated methylsulfonylbenzamide derivative and exists as a white to brownish powder. Effects Vismodegib (ATC L01XX43) has antitumor properties. The effects are due to inhibition … Vismodegib

Meprobamate

Products Meprobamate was commercially available in tablet form (Meprodil, 400 mg). It was approved in many countries in 1957 and was withdrawn from the market on October 31, 2012. The French Medicines Agency revoked the approval back in January 2012 due to the potential adverse effects and toxicity. The European Medicines Agency (EMA) also concluded … Meprobamate

Topiramate

Products Topiramate is commercially available in tablet and capsule form (Topamax, generic). It has been approved in many countries and in the United States since 1996. Structure and properties Topiramate (C12H21NO8S, Mr = 339.36 g/mol) lies as a white powder with a bitter taste that is soluble in water. It is a sulfamate-substituted monosaccharide. Effects … Topiramate