Tobacco Dependence: Causes
Pathogenesis (development of disease) Cigarette smoke contains more than 4,000 substances that have very different modes of action. Nicotine mediates neurobiological effects; for example, it has stimulating, appetite-reducing, rewarding, vigilance-increasing, and sedative effects. The psychotropic effects are manifold and are due to the nicotine-mediated release of dopamine, serotonin, norepinephrine or beta-endorphin. Physical dependence results from … Tobacco Dependence: Causes