To prevent plasmacytoma, attention must be paid to reducing individual risk factors.
Behavioral risk factors
- Diet
- Micronutrient deficiency (vital substances) – see Prevention with micronutrients.
- Overweight (BMI ≥ 25; obesity).
Environmental pollution – intoxications (poisoning).
- Ionizing radiation
- The following groups of people are frequently affected:
- Workers in wood processing
- Workers in the leather industry
- Farmers
- Persons with exposure to mineral oil
Prevention factors (protective factors)
- Genetic factors:
- Genetic risk reduction depending on gene polymorphisms:
- Genes/SNPs (single nucleotide polymorphism):
- Gene: CASP9
- SNP: rs1052576 in gene CASP9
- Allele constellation: AG (0.80-fold).
- Allele constellation: AA (0.50-fold)
- Genes/SNPs (single nucleotide polymorphism):
- Genetic risk reduction depending on gene polymorphisms:
- High versus low leisure-time physical activity was associated with a lower risk of plasmacytoma (HR 0.83, 95% CI 0.72-0.95).