Products
Sunovion’s dasotraline is in the regulatory phase and is therefore not yet available.
Structure and properties
Dasotralin (C16H15Cl2N, Mr = 292.2 g/mol) is a diastereomer of the desmethyl metabolite of sertraline (Zoloft, generics).
Effects
Dasotraline selectively inhibits the reuptake of the neurotransmitters dopamine and norepinephrine into presynaptic neurons in the central nervous system. The effects are due to inhibition of the corresponding transporters DAT and NET. Promotion of neurotransmission is associated with improvement of symptoms.
Indications
For the treatment of attention-deficit/hyperactivity disorder (ADHD). The agent is also being studied for the treatment of binge eating disorder.
Dosage
According to the SmPC. Because of its long half-life (47 to 77 hours), once-daily dosing is sufficient.
Abuse
Unlike amphetamines such as methylphenidate (e.g., Ritalin), this is not a stimulant and not a narcotic. The potential for abuse is considered low.
Contraindications
For complete precautions, see the drug label.
Adverse effects
The most common possible adverse effects include insomnia, poor appetite, and dry mouth.
