Duodenal Ulcer: Prevention

To prevent duodenal ulcer (ulcer of the duodenum), attention must be paid to reducing individual risk factors.

Behavioral risk factors

• Diet
  • High consumption of mono- and disaccharides such as white flour products and confectionery products
  • Rare intake of omega-3 and -6 fatty acids.
  • Excessive intake of table salt
  • Micronutrient deficiency (vital substances) – see Prevention with micronutrients.
• Consumption of stimulants
  • Coffee (high consumption)
  • Alcohol
  • Tobacco (smoking)
• Drug use
  • Cocaine
• Psycho-social situation
  • Psychological stress – increase in the incidence (frequency of new cases) of peptic ulcers (presence of acid as a prerequisite for the development of the ulcer).

Medication

• Acetylcholinesterase inhibitors (donezepil, galantamine, rivastigmine).
• Aldosterone antagonists (epleronone, spironolactone).
• Analgesics
  • Non-steroidal anti-inflammatory drugs (NSAIDs), non-steroidal/NSAID (non steroidal anti-inflammatory drugs – acetylsalicylic acid (ASA), acemeatcin, diclofenac, etoricoxib, indometacin, ibuprofen, ketoprofen, meloxicam, naproxen, phenylbutazone piroxicam); concomitant use of glucocorticoids increases the likelihood of disease by a factor of 15.
• Bisphosphonates
• Hormones
  • Glucocorticoids (alclometasone, betamethasone valerate, budesonide, fluticasone, halometasone, hydrocortisone, methylprednisolone, mometasone, prednicarbate, prednisone, prednisolone) [especially in combination with NSAIDs (nonsteroidal anti-inflammatory drugs)]
• Immunosuppressants (mycofenolate mofetil).
• Potassium chloride
• Platelet aggregation inhibitors – acetylsalicylic acid (ASA), clopidogrel.
• Cytostatic drugs