Medical history (history of illness) represents an important component in the diagnosis of somatopause. Family history Social history What is your occupation? Is there any evidence of psychosocial stress or strain due to your family situation? Current medical history/systemic history (somatic and psychological complaints). What symptoms have you noticed in yourself? Reduced energy and vitality … Somatopause: Medical History
Endocrine, nutritional, and metabolic diseases (E00-E90). Obesity (overweight)-particularly with android body fat distribution, that is, abdominal, truncal, central body fat (apple type). Andropause (menopause of the male) Diabetes mellitus – is accompanied by hyperglycemia (hyperglycemia), which inhibits growth hormone production. Hemochromatosis (iron storage disease) – genetic disease with autosomal recessive inheritance with increased deposition of … Somatopause: Or something else? Differential Diagnosis
General measures Nicotine restriction (refraining from tobacco use). Limited alcohol consumption (men: max. 25 g alcohol per day; women: max. 12 g alcohol per day). Aim for normal weight! Determination of BMI (body mass index, body mass index) or body composition using electrical impedance analysis. BMI ≥ 25 → participation in a medically supervised weight … Somatopause: Therapy
Laboratory parameters of the 1st order – obligatory laboratory tests. IGF-1 (insulin-like growth factor). IGFBP-3 (insulin-like-growth-factor-binding-protein-3) Laboratory parameters 2nd order – depending on the results of the history, physical examination, etc. – for differential diagnostic clarification. Hormone diagnostics: DHEA-S, total testosterone, SHBG (sex hormone-binding globulin), FSH, prolactin, TSH, estradiol if necessary, pituitary function test (test … Somatopause: Lab Test
Therapeutic target The goal of STH substitution therapy is: Raise serum IGF-1 concentrations to the mid-normal range – 50th percentile (200-210 ng/ml) – of a healthy 25- to 30-year-old plus. By STH deficiency (growth hormone deficiency) caused complaints or disorders to remedy or alleviate. Therapy recommendations STH substitution (growth hormone replacement therapy). Indications (areas of … Somatopause: Drug Therapy
Obligatory medical device diagnostics. Transrectal prostate sonography (ultrasound examination of the prostate). Electrical impedance analysis (measurement of body compartments/body composition) – for determination of body fat, extracellular body mass (blood and tissue fluid), body cell mass (muscle and organ mass) and total body water incl. body mass index (BMI, body mass index) and waist-to-hip ratio … Somatopause: Diagnostic Tests
Micronutrient therapy (vital substances) is a useful complementary measure in the context of somatopause therapy Compensation of vital substance deficits (vital substances) – determination of individual vital substance additional requirements (macro- and micronutrients; vital substance supplementation). Improvement of antioxidant capacity – Determination of oxidative stress (vital substance supplementation).
To prevent somatopause, that is, to delay its onset, attention must be paid to reducing individual risk factors. Behavioral risk factors Diet Excessive fat and carbohydrate intake with associated elevation of blood lipids (blood fat levels). Consumption of stimulants Alcohol – (woman: > 20 g/day; man: > 30 g/day). Physical activity Physical inactivity Psycho-social situation … Somatopause: Prevention
Symptomatology of somatopause is characterized in men and women alike by mood disorders, physical and mental performance decline, and physiological failure symptoms.The following is an overview of typical complaints in somatopause:Psychological disorders. Reduced energy and vitality Impaired self-control Disturbed emotional reactions Lack of well-being Depressed mood Increased anxiety Increased social isolation Organic disorders Reduced physical … Somatopause: Symptoms, Complaints, Signs
Pathogenesis (development of disease) The STH deficiency of healthy adults in middle and advanced age, termed somatopause, originates exclusively from the age-related exponential decline in STH secretion (site of synthesis: anterior pituitary) beginning at about age 24. Etiology (Causes) Biographic causes Genetic burden Genetic diseases Hemochromatosis (iron storage disease) – genetic disease with autosomal recessive … Somatopause: Causes
The following are the most important diseases or complications that may be contributed to by somatopause: Respiratory system (J00-J99) Decreased total lung capacity, increased work of breathing, especially at night!!! Endocrine, nutritional and metabolic diseases (E00-E90). Insulin resistance – decreased effectiveness of endogenous insulin at target organs skeletal muscle, adipose tissue, and liver. Hyperlipoproteinemia (increased … Somatopause: Complications
A comprehensive clinical examination is the basis for selecting further diagnostic steps: General physical examination – including blood pressure, pulse, body weight, height; further: Inspection (viewing). Skin, mucous membranes, and sclerae (white part of eye) [sweating, heat exhaustion; visceral adiposity* (abdominal fat ↑), decreased muscle mass (muscle strength ↓); increased waist-to-hip ratio, thin and dry … Somatopause: Examination
