Chondroblastoma

Chondroblastoma: Or something else? Differential Diagnosis

Musculoskeletal system and connective tissue (M00-M99). Aneurysmal bone cyst (AKZ) – tumor-like osteolytic lesions (“bone loss”) with dark red to brownish cavities up to 14 cm3 in size. Neoplasms – tumor diseases (C00-D48). Chondromyxoid fibroma – rare, chondroplastic bone tumor. Clear cell chondrosarcoma – low malignant (malignant) bone tumor that accounts for approximately 2% of … Chondroblastoma: Or something else? Differential Diagnosis

Chondroblastoma: Complications

The following are the most important diseases or complications that may be contributed to by chondroblastoma: Musculoskeletal system and connective tissue (M00-M99). Restriction of movement due to limitation of joint activity. Secondary osteoarthritis (joint wear) – in the case of chondroblastoma close to the joint surface, esp. at the proximal (towards the center of the … Chondroblastoma: Complications

Chondroblastoma: Examination

A comprehensive clinical examination is the basis for selecting further diagnostic steps: General physical examination – including blood pressure, pulse, body weight, height; further: Inspection (viewing). Skin and mucous membranes Neck Extremities: [swelling? Size; consistency; displaceability of skin relative to underlying surface. Deformity of joints and bones?] Spine, thorax (chest). Gait pattern (fluid, limping) Body … Chondroblastoma: Examination

Chondroblastoma: Medical History

Medical history (history of illness) represents an important component in the diagnosis of chondroblastoma. Family history Are there any diseases in your family that are common? (Tumor diseases) Social anamnesis Current medical history/systemic history (somatic and psychological complaints). Do you suffer from persistent or increasing pain in the skeletal system for which there is no … Chondroblastoma: Medical History

Chondroblastoma: Test and Diagnosis

1st order laboratory parameters – obligatory laboratory tests. Biopsy (tissue sample) – for differential diagnostic reasons. Immunohistochemical detection of mutant H3.3 histone protein – for unclear cases.

Chondroblastoma: Drug Therapy

Therapeutic targets Relief of pain Removal of the tumor – see “Surgical Therapy“. Healing Therapy recommendations Analgesia according to WHO staging scheme: Non-opioid analgesic (paracetamol, first-line agent). Low-potency opioid analgesic (e.g., tramadol) + non-opioid analgesic. High-potency opioid analgesic (eg, morphine) + non-opioid analgesic.

Chondroblastoma: Diagnostic Tests

Mandatory medical device diagnostics. Conventional radiography of the affected body region, in two planes – to assess the extent of tumor growth; characteristically, one: Epiphyseal/epimetaphyseal eccentric location of the osteolytic area (sharply defined area of bone dissolution) with round to oval shape. Geographic osteolysis is often surrounded by a sclerotic space The cortical bone (outer … Chondroblastoma: Diagnostic Tests

Chondroblastoma: Surgical Therapy

The location and extent of chondroblastoma usually require intralesional resection (excision): Procedure: Opening of the tumor → curettage → filling of the bone defect with autologous (patient-derived) cancellous bone (internal, bony network of bone substance). Depending on the situation, a so-called bone cement plug can be used temporarily → Advantage: the tumor cells of the … Chondroblastoma: Surgical Therapy

Chondroblastoma: Symptoms, Complaints, Signs

The clinical picture of a chondroblastoma depends on its size or extent as well as its location. Usually, a chondroblastoma is initially asymptomatic and therefore usually an incidental finding on radiography. The following symptoms and complaints may indicate a chondroblastoma: Main symptoms Mild to moderate (moderate) joint pain, pain on movement. Restriction of mobility of … Chondroblastoma: Symptoms, Complaints, Signs

Chondroblastoma: Causes

Pathogenesis (disease development) Chondroblastoma (Codman tumor) originates from chondroblasts (cartilage-forming cells). It forms a cartilaginous matrix (“immature cartilage“) with calcifications (calcifications). Chondroblastoma also contains giant cells, but is to be distinguished from giant cell tumor. It originates in the secondary ossification centers (= “bone nuclei”) of the epiphyses, which develop before the ossification of the … Chondroblastoma: Causes

Chondroblastoma: Therapy

General measures Nicotine restriction (refraining from tobacco use). Limited alcohol consumption (men: max. 25 g alcohol per day; women: max. 12 g alcohol per day). Limited caffeine consumption (max 240 mg of caffeine per day; equivalent to 2 to 3 cups of coffee or 4 to 6 cups of green/black tea). Aim for normal weight! … Chondroblastoma: Therapy