Hepatitis E

Hepatitis E: Or something else? Differential Diagnosis

Endocrine, nutritional, and metabolic diseases (E00-E90). Alpha-1 antitrypsin deficiency. Hemochromatosis (iron storage disease) – genetic disease with autosomal recessive inheritance with increased deposition of iron as a result of increased iron concentration in the blood with tissue damage. Wilson’s disease (copper storage disease) – autosomal recessive inherited disease in which copper metabolism in the liver … Hepatitis E: Or something else? Differential Diagnosis

Hepatitis E: Complications

The following are the most important diseases or complications that may be contributed to by hepatitis E: Blood-forming organs – Immune system (D50-D90). Aplastic anemia – form of anemia (anemia) characterized by pancytopenia (synonym: tricytopenia; reduction of all three rows of cells in the blood; stem cell disease) and concomitant hypoplasia (functional impairment) of the … Hepatitis E: Complications

Hepatitis E: Examination

A comprehensive clinical examination is the basis for selecting further diagnostic steps: General physical examination – including blood pressure, pulse, body temperature, body weight, body height; further: Inspection (viewing). Skin, mucous membranes, and sclerae (white part of the eye) [jaundice (jaundice)?, exanthema (rash), unspecified?] Abdomen (abdomen) Shape of the abdomen? Skin color? Skin texture? Efflorescences … Hepatitis E: Examination

Hepatitis E: Lab Test

1st order laboratory parameters – obligatory laboratory tests. Serology* – Detection of hepatitis E-specific antibodies [Note: In transplanted patients, months to years may pass before measurable antibodies are produced in the setting of chronic hepatitis E! → HEV RNA by PCR, see below] HEV antigen detection (hepatitis E antigen) in blood or stool [indicates fresh … Hepatitis E: Lab Test

Hepatitis E: Drug Therapy

Therapeutic targets Improvement of the symptomatology Avoidance of complications Virus elimination, i.e. cure Therapy recommendations Acute hepatitis E In healthy individuals, no specific therapy is usually required, as spontaneous viral elimination occurs in immunocompetent individuals after a few weeks. Therapy with ribavirin in: Immunosuppressed individuals Pregnant women: in pregnant women who suffer a fulminant course … Hepatitis E: Drug Therapy

Hepatitis E: Diagnostic Tests

Optional medical device diagnostics – depending on the results of the history, physical examination, laboratory diagnostics, and obligatory medical device diagnostics – for differential diagnostic clarification. Abdominal ultrasonography (ultrasound examination of the abdominal organs) – for basic diagnostics. Computed tomography (CT) of the abdomen (abdominal CT) – for advanced diagnostics.

Hepatitis E: Prevention

Hepatitis E vaccination is the most important and effective preventive measure (currently not available in Europe). To prevent hepatitis E, attention must be paid to reducing individual risk factors. Behavioral risk factors Drinking contaminated water Eating contaminated food – especially insufficiently cooked or raw pork, game, shellfish – the virus can be inactivated by heating … Hepatitis E: Prevention

Hepatitis E: Medical History

Medical history (history of illness) represents an important component in the diagnosis of hepatitis E. Family history What is the general health status of your family members? Social history Have you recently been to countries with low hygienic standards (Africa, Asia, Central/South America). Have you consumed raw food there? Did you consume drinks with ice … Hepatitis E: Medical History

Hepatitis E: Symptoms, Complaints, Signs

Most cases of hepatitis E infection in Germany are caused by HEV genotype 3, which is predominantly asymptomatic,i.e., without symptoms. The following symptoms and complaints may indicate hepatitis E: Leading symptoms Icterus (jaundice) Pruritus (itching) Upper abdominal pain Exanthema (skin rash), unspecified Dark urine Light stool Concomitant symptoms (nonspecific and extrahepatic manifestations/occurrence outside the liver). … Hepatitis E: Symptoms, Complaints, Signs

Hepatitis E: Causes

Pathogenesis (disease development) Hepatitis E virus (HEV) belongs to the group of RNA viruses. It used to be considered part of theFamily Caliciviridae, but it is now considered to belong to the monotypic family Hepeviridae. HEV genotypes 1-4 can be distinguished. HEV 1 and HEV 2 are mostly responsible for rice infection. HEV 3 and … Hepatitis E: Causes

Hepatitis E: Therapy

General therapeutic measures Observance of the general hygiene measures! Symptomatic therapy (analgesics / painkillers and antipyretics / antipyretics). Alcohol abstinence (complete abstinence from alcohol). Nicotine restriction (refrain from tobacco use). If hospitalized, isolation (such as hepatitis A). Regular checkups Regular medical checkups Nutritional medicine After the acute phase of the disease, if necessary, nutritional counseling … Hepatitis E: Therapy