Leukoplakia of the Oral Mucosa

Leukoplakia of Oral Mucosa: Therapy

General measures Consistently avoid causal external irritants (skin-damaging irritants): Cheek or lip chewing Poorly fitting dentures Nicotine restriction (refraining from tobacco use). Alcohol restriction (renunciation of alcohol consumption) Avoidance of psychosocial stress: Morsicatio (habitual cheek chewing). Avoidance of environmental stress: UV radiation (lip area) Regular checkups Regular medical checkups Nutritional medicine Nutritional counseling based on … Leukoplakia of Oral Mucosa: Therapy

Leukoplakia of Oral Mucosa: Dental Therapy

Conventional nonsurgical therapeutic procedures Initial therapy: removal of possible etiologic factors: Mechanically irritative tooth edges/restorations. Modification or new fabrication of ill-fitting dentures Clinical control after elimination of the possible causes until complete regression of leukoplakia. Without regression tendency after two weeks referral to specialist control / biopsy. Systematic follow-up controls Every six months in the … Leukoplakia of Oral Mucosa: Dental Therapy

Leukoplakia of Oral Mucosa: Drug Therapy

Therapeutic target Removal of the leukoplakia Therapy recommendations Eliminate Candida infection as a possible etiological (“causative”) factor. Alternative to surgical therapy: removal of a leukoplakia. By systemic therapy with retinoids and beta-carotene (Provitamín A). With bleomycin (antibiotic; cytostatic). With calcipotriol (anti-inflammatory agent from the group of vitamin D3 derivatives). The main disadvantages of most of … Leukoplakia of Oral Mucosa: Drug Therapy

Leukoplakia of Oral Mucosa: Diagnostic Tests

Leukoplakia of the oral mucosa is usually diagnosed on the basis of history, clinical course, and physical examination. Further medical device diagnostics may be required for differential diagnosis. Optional medical device diagnostics – depending on the results of the history, physical examination, laboratory diagnostics – for differential diagnostic clarification. X-rays

Leukoplakia of Oral Mucosa: Surgical Therapy

1. dental surgery Removal of non-salvageable, sharp-edged, mechanically irritating teeth/root debris. 2. oral and maxillofacial surgery. Biopsy (tissue sample) – if a precursor lesion is suspected: any lesion without a tendency to regress after elimination of an adequate cause or observation for two weeks is considered suspicious. Without/mild epithelial dysplasia (SIN I): Initially, further observation … Leukoplakia of Oral Mucosa: Surgical Therapy

Leukoplakia of Oral Mucosa: Prevention

To prevent leukoplakia of the oral mucosa, attention must be paid to reducing individual risk factors. Most leukoplakias do not undergo malignant transformation and can regress if etiologic factors are avoided. Behavioral risk factors Diet Poor dietary habits (malnutrition and malnutrition). Vitamin deficiency (A, C) or risk group for folic acid deficiency. Consumption of stimulants … Leukoplakia of Oral Mucosa: Prevention

Leukoplakia of Oral Mucosa: Symptoms, Complaints, Signs

The following symptoms and complaints may indicate leukoplakia of the oral mucosa: Leukoplakias of the oral mucosa may be single or multiple. They cannot be wiped away. Localizations (most commonly affected): buccal mucosa (buccal mucosa), mucosa of the alveolar processes (part of the jaw where the dental compartments = alveoli are located), floor of the … Leukoplakia of Oral Mucosa: Symptoms, Complaints, Signs

Leukoplakia of Oral Mucosa: Causes

Pathogenesis (development of disease) The clinical finding of predominantly white mucosal change correlates histopathologically with hyperkeratosis (increased keratinization) and dyskeratosis of the squamous epithelium. The white color results from swelling of the keratinized cells. Genetic mutations are assumed to be the cause of the dysplastic changes. The more pronounced the dysplasia (deviation of the tissue … Leukoplakia of Oral Mucosa: Causes

Leukoplakia of Oral Mucosa: Medical History

In addition to the diagnostic findings, the medical history represents an important component in the diagnosis of leukoplakia. The diagnosis of leukoplakia can only be made by excluding all defined diseases associated with white mucosal changes. Family history What is the general health of your family? Are there any common diseases in your family? Social … Leukoplakia of Oral Mucosa: Medical History

Leukoplakia of Oral Mucosa: Or something else? Differential Diagnosis

Congenital malformations, deformities, and chromosomal abnormalities (Q00-Q99). Dyskeratosis follicularis Nevus spongiosus albus (white sponge nevus) Palmar plantar keratoses Skin and subcutaneous (L00-L99) Discoid lupus erythematosus (DLE) Lichenoid reactions – lichen-like skin changes. Oral lichen planus (OLP) Pachyderma – mechanically irritative leukoplakia. Infectious and parasitic diseases (A00-B99). Oral candidiasis (candida stomatitis, oral thrush). Diphtheria Syphilis (Lues) … Leukoplakia of Oral Mucosa: Or something else? Differential Diagnosis

Leukoplakia of Oral Mucosa: Consequential Diseases

The most important diseases or complications that may be contributed to by leukoplakia of the oral mucosa are: Infectious and parasitic diseases (A00-B99). Oral candidiasis [Candida-infected leukoplakia] Mouth, esophagus (food pipe), stomach and intestines (K00-K67; K90-K93). Erythroleukoplakia Neoplasms – tumor diseases (C00-D48) Carcinoma in situ within leukoplakia → transition to invasive squamous cell carcinoma. Injury, … Leukoplakia of Oral Mucosa: Consequential Diseases

Leukoplakia of Oral Mucosa: Classification

Leukoplakia is defined as a white, nonwipeable patch of the mucosa that cannot be assigned to any other disease. Synopsis of the classification of oral precursor lesions. WHO 2005:Dysplasia Ljubljana classification squamous intraepithelial lesions (SIL). Squamous intraepithelial neoplasia (SIN). Squamous intraepithelial neoplasia (SIN) reduced SquamousHyperplasia Squamous (simple)hyperplasia – – – – MinorDysplasia Basal and parabasal … Leukoplakia of Oral Mucosa: Classification