Irritable Stomach (Functional Dyspepsia): Or something else? Differential Diagnosis

Respiratory System (J00-J99)

  • Chronic pulmonary disease

Endocrine, nutritional and metabolic diseases (E00-E90).

  • Diabetes mellitus

Cardiovascular system (I00-I99)

Infectious and parasitic diseases (A00-B99).

  • Parasites (e.g., Giardia lamblia, Strongyloides, Anisakis).

Liver, gallbladder, and bile ducts – Pancreas (pancreas) (K70-K77; K80-K87).

Mouth, esophagus (esophagus), stomach, and intestines (K00-K67; K90-K93).

  • Chronic mesenteric ischemia – chronic decreased blood flow to the “abdominal vessels“.
  • Diffuse esophageal spasm – neuromuscular dysfunction of esophageal muscles with intermittent retrosternal (localized behind the sternum) pain
  • Eosinophilic gastroenteritis (EGS; synonym: diffuse eosinophilic infiltration of the gastrointestinal tract).
  • Gastritis (gastritis), acute and chronic.
  • Gastroduodenal ulcer disease (ulcer of the stomach or duodenum).
  • Gastroenteritis (gastrointestinal flu).
  • Gastroesophageal reflux disease (synonyms: GERD, gastroesophageal reflux disease; gastroesophageal reflux disease (GERD); gastroesophageal reflux disease (reflux disease); gastroesophageal reflux; reflux esophagitis; reflux disease; Reflux esophagitis; peptic esophagitis) – inflammatory disease of the esophagus (esophagitis) caused by the pathological reflux (reflux) of acid gastric juice and other gastric contents.
  • Gastroparesis – motility disorder (movement disorder) of the stomach.
  • Hypercontractile esophagus (nutcracker esophagus) – motility disorder (movement disorder) of the esophagus characterized by high pressure amplitudes in the lower esophagus.
  • Crohn’s disease – chronic inflammatory bowel disease; it usually runs in relapses and can affect the entire digestive tract; characteristic is the segmental affection of the intestinal mucosa (intestinal mucosa), that is, several intestinal sections may be affected, which are separated by healthy sections from each other
  • Motility disorders of the esophagus (eg, achalasia: disease in which the lower esophageal sphincter (esophageal sphincter) does not open properly and the motility (mobility) of the muscles of the esophagus is also disturbed)
  • Food intolerances, which can be very individual, such as dairy products (lactose intolerance), coffee, spicy foods, fruit (fructose intolerance); sorbitol intolerance (sorbitol intolerance).
  • Esophagitis (esophagitis).
  • Esophageal achalasia – dysfunction of the esophagus with lack of smooth muscle relaxation due to degeneration of a plexus of nerves in the lower portion of the esophagus.
  • Esophageal diverticulum – protrusions of mucosa through the muscular layer of the esophagus.
  • Esophageal ulcers – ulcers in the esophageal mucosa.
  • Celiac disease (gluten-induced enteropathy) – disease of the mucosa of the small intestine (small intestinal mucosa), which is based on hypersensitivity to the grain protein gluten.

Neoplasms – tumor diseases (C00-D48).

  • Gallbladder carcinoma
  • Gastric carcinoma (stomach cancer)
  • Esophageal carcinoma (cancer of the esophagus)
  • Pancreatic carcinoma (cancer of the pancreas)

Psyche – nervous system (F00-F99; G00-G99)

  • Depression
  • Psychosomatic disorders

Symptoms and abnormal clinical and laboratory findings not elsewhere classified (R00-R99).

  • Meteorism (flatulence)
  • Pyrosis (heartburn)

Medication

  • ACE inhibitors
  • Calcium antagonists
  • Iron supplements
  • Gucocorticoids
  • Methylxanthine
  • Nonsteroidal anti-inflammatory drugs (NSAIDs or NSAs; also called nonsteroidal anti-inflammatory drugs (NSAPs) or NSAIDs.