ace inhibitors

Lithium: Drug Effects, Side Effects, Dosage and Uses

Products Lithium is commercially available in the form of tablets and sustained-release tablets (e.g., Quilonorm, Priadel, Lithiofor). Structure and properties The lithium ion (Li+) is a monovalent cation found in pharmaceuticals in the form of various salts. These include lithium citrate, lithium sulfate, lithium carbonate, and lithium acetate. For example, lithium carbonate (Li2CO3, Mr = … Lithium: Drug Effects, Side Effects, Dosage and Uses

Trandolapril

Products Trandolapril is commercially available in the form of film-coated tablets in combination with verapamil (Tarka). It has been approved in many countries since 1994. The monopreparation Gopten was withdrawn from the market in 2014. Structure and properties Trandolapril (C24H34N2O5, Mr = 430.5 g/mol) exists as a white powder that is soluble in organic solvents. … Trandolapril

Valsartan

Products Valsartan is commercially available in the form of film-coated tablets and has been approved since 1996 (Diovan, generic). The active ingredient is also combined fixed with other agents: Hydrochlorothiazide (co-Diovan, Exforge HCT with amlodipine, generics). Amlodipine (Exforge, generic). Sacubitril (Entresto) Valsartan scandal: in July 2018, numerous generic drugs had to be recalled from the … Valsartan

Captopril Effects and Side Effects

Products Captopril was approved in many countries in 1980 as the first active ingredient in the ACE inhibitor group. The original Lopirin is now off the market. Generic products are available in tablet form. Structure and properties Captopril (C9H15NO3S, Mr = 217.3 g/mol) is a derivative of the amino acid proline. It exists as a … Captopril Effects and Side Effects

Enalapril: Drug Effects, Side Effects, Dosage and Uses

Products Enalapril is commercially available in tablet form (Reniten, generics). It has been approved in many countries since 1984. The active ingredient is also combined fixed with hydrochlorothiazide. Structure and properties Enalapril (C20H28N2O5, 376.45 g/mol) is present in drugs as enalapril maleate, a white powder that is sparingly soluble in water. Enalapril is the prodrug … Enalapril: Drug Effects, Side Effects, Dosage and Uses

Firocoxib

Products Firocoxib is commercially available as chewable tablets for dogs and as a paste for administration in horses. It has been approved in many countries since 2004. Structure and properties Firocoxib (C17H20O5S, Mr = 336.4 g/mol) is a furanone derivative. Like other COX-2 inhibitors, it has a V-shaped structure that allows binding to the Active … Firocoxib

Metabolism (Biotransformation)

Introduction Biotransformation is an endogenous pharmacokinetic process that leads to a change in the chemical structure of active pharmaceutical ingredients. The organism’s general goal in doing so is to make the foreign substances more hydrophilic and to direct them to excretion via the urine or stool. Otherwise, they could be deposited in the body and … Metabolism (Biotransformation)

Perindopril

Products Perindopril is commercially available in the form of film-coated tablets and has been approved in many countries since 1989 (Coversum N, generic). It is also approved as a fixed combination with indapamide (Coversum N combi, generic) or amlodipine (Coveram, generic). Generic of the fixed combination with amlodipine was first registered in many countries in … Perindopril

Lithium Therapy: Treatment, Effects & Risks

Lithium therapy is used for affective disorders and treatment-resistant schizophrenia. Lithium causes mood stabilization and is the only known drug that has been shown to have a suicide-preventive effect. What is lithium therapy? Lithium therapy, used in psychiatry, involves administering lithium to stabilize mood. The use of lithium as a drug in the context of … Lithium Therapy: Treatment, Effects & Risks

Renin-Angiotensin-Aldosterone System (RAAS)

Effects The RAAS is activated in the presence of low blood pressure, decreased blood volume, hyponatremia, and sympathetic activation. Main actions: mediated via angiotensin II: Vasoconstriction Blood pressure increase Release of catecholamines Hypertrophy at the heart Mediated via aldosterone: Water and sodium ions are retained Potassium ions and protons are eliminated Overview of the RAAS … Renin-Angiotensin-Aldosterone System (RAAS)

Canrenon

Products Canrenone is commercially available as an injectable (Soldactone). It has been approved in many countries since 1975. Structure and properties Canrenone (C22H28O3, Mr = 340.5 g/mol) is an active metabolite of spironolactone (aldactone) and, unlike the latter, is soluble in water. Canrenone is present in drugs as potassium canrenoate, the potassium salt of canrenoic … Canrenon

Gliclazide

Products Gliclazide has been commercially available in sustained-release tablet form and approved in many countries since 1978. The sustained-release dosage forms entered the market in 2001. In addition to the original Diamicron MR, sustained-release generics have been available since 2008. Sales of the non-retarded Diamicron 80 mg were discontinued in 2012. Structure and properties Gliclazide … Gliclazide