Products BIA 10-2474 is in clinical development at the Portuguese pharmaceutical company Bial. It is not commercially available. Structure and properties BIA 10-2474 is the following urea and imidazole derivative: Effects BIA 10-2474 is a long-acting inhibitor of the enzyme FAAH (fatty acid amide hydrolase). This enzyme is involved in the breakdown of fatty acid … BIA 10-2474
Products Almotriptan is commercially available in the form of film-coated tablets (Almogran). It has been approved in many countries since 2004. Structure and properties Almotriptan (C17H25N3O2S, Mr = 335.5 g/mol) is present in drugs as almotriptan-D,L-hydrogenmalate, a white to slightly yellowish crystalline powder that is soluble in water. Effects Almotriptan (ATC N02CC05) has vasoconstrictive, analgesic, … Almotriptan for Migraine Headache
Products Tafluprost is available in the form of eye drops (saflutane). It was approved in many countries in 2010. In 2016, a fixed combination with timolol was also registered (Taptiqom). Structure and properties Tafluprost (C25H34F2O5, Mr = 452.53 g/mol) is a fluorinated analog of prostaglandin F2α (Figure). It is a prodrug and is converted at … Tafluprost
Products Tamoxifen is commercially available in the form of film-coated tablets (Nolvadex, generic). It was synthesized in 1962 and tested as a contraceptive (“morning-after pill”) but was not suitable for this purpose. It was first used as a breast cancer drug in the early 1970s. It has been approved in many countries since 1976. Structure … Tamoxifen (Nolvadex): Drug Effects, Side Effects, Dosage and Uses
Products Tasimelteon was approved in the United States in 2014 and in the EU in 2015 in capsule form (Hetlioz). The drug is not currently registered in many countries. Structure and properties Tasimelteon (C15H19NO2, Mr = 245.3 g/mol) exists as a white crystalline powder that is sparingly soluble in water. It is structurally related to … Tasimelteon
Products Alitretinoin is commercially available in capsule form (Toctino) and was approved in many countries in 2009. Structure and properties Alitretinoin (C20H28O2, Mr = 300.4 g/mol) is a retinoid like the acne drugs isotretinoin (13- retinoic acid) or tretinoin (all-retinoic acid). Effects Alitretinoin (ATC D11AX19) has anti-inflammatory and immunomodulatory properties. Unlike other retinoids, it acts … Alitretinoin
Products Vortioxetine is commercially available as film-coated tablets and as an oral solution (drops). It was approved in the United States and the EU in 2013 and in many countries in 2016 (Brintellix, United States: Trintellix). Structure and properties Vortioxetine (C18H22N2S, Mr = 298.4 g/mol) is a piperazine derivative. It is present in the film-coated … Vortioxetine
Products Pitolisant (formerly tiprolisant) is commercially available in the form of film-coated tablets (Wakix). It was approved in the EU in 2016, in many countries in 2018, and in the United States in 2019. Structure and properties Pitolisant (C17H26ClNO, Mr = 295.8 g/mol) is a piperidine derivative and an ether. Effects Pitolisant (ATC N07XX11) is … Pitolisant
Products Betahistine is commercially available in the form of tablets and drops (Betaserc, generic). It has been approved in many countries since 1971. Structure and properties Betahistine (C8H12N2, Mr = 136.19 g/mol) exists as betahistine dihydrochloride, a white to pale yellow, very hygroscopic powder that is very soluble in water. Betahistine dimesilate is also present … Betahistine
Products Bethanechol chloride is commercially available in tablet form (Myocholine-Glenwood). It has been approved in many countries since 1977. Structure and properties Bethanechol chloride (C7H17ClN2O2, Mr = 196.67 g/mol) is structurally closely related to the neurotransmitter acetylcholine. Effects Bethanechol chloride (ATC N07AB02) has parasympathomimetic (cholinergic) properties. It is an agonist at acetylcholine receptors. Bethanechol chloride … Bethanechol Chloride
Products Pioglitazone is commercially available in tablet form (Actos, generics). It is also available as a fixed-dose combination with metformin (Competact). Pioglitazone has been approved in many countries since 2000. Structure and properties Pioglitazone (C19H20N2O3S, Mr = 356.4 g/mol) belongs to the thiazolidinediones. It is present in drugs as a racemate and as pioglitazone hydrochloride, … Pioglitazone
Products Lasmiditan was approved in the United States in 2019 in film-coated tablet form (Reyvow). Structure and properties Lasmiditan (C19H18F3N3O2, Mr = 377.4 g/mol) is present in the drug as lasmiditanhemisuccinate, a white crystalline powder that is sparingly soluble in water. It is a piperidine and pyridine derivative and has no indole structure. Effects Lasmiditan … Lasmiditan
