Symptoms Drug-induced prolongation of the QT interval can rarely lead to severe arrhythmias. This is polymorphic ventricular tachycardia, known as torsade de pointes arrhythmia. It can be seen on the ECG as a wave-like structure. Due to the dysfunction, the heart cannot maintain blood pressure and can only pump insufficient blood and oxygen to the … Prolongation of the QT Interval
Diseases such as gastritis, peptic ulcer, or the use of medications that are harmful to the stomach may require the use of a stomach-protecting, acid-inhibiting agent. Modern medicine has a number of appropriate drugs available that work effectively and gently. One of the most commonly prescribed agents is omeprazole. What is omeprazole? The active ingredient … Omeprazole: Effects, Uses & Risks
Astemizole is a so-called antihistamine, which is used to treat allergies symptomatically. However, this drug is no longer available on the German market. What is astemizole? Astemizole is a so-called antihistamine, which is used to treat allergies symptomatically. Astemizole is an H1 receptor antagonist as well as a second-generation antihistamine. By blocking the histamine receptors, … Astemizole: Effects, Uses & Risks
The drug prochlorperazine is used in human medicine primarily as a medication for nausea, vomiting, and migraine. Occasionally, the dopamine antagonist is also prescribed to treat psychiatric or mental illness. Accordingly, prochlorperazine is both an antiemetic and a neuroleptic. What is prochlorperazine? The active medical ingredient prochlorperazine belongs to the group of antiemetics. This term … Prochlorperazine: Effects, Uses & Risks
Products Astemizole was commercially available in tablet and suspension form (Hismanal). It has been withdrawn from the market in many countries because of potential adverse effects and is no longer available (see below). It may well be replaced by other, better-tolerated antihistamines, such as cetirizine, loratadine, and fexofenadine. Structure and properties Astemizole (C28H31FN4O, Mr = … Astemizole
Products Antihistamines are often taken in the form of tablets. In addition, drops, solutions, lozenges, capsules, gels, creams, eye drops, nasal sprays, and injectable solutions are also available, among others. The first active ingredient from this group was phenbenzamine (Antergan), developed in France in the 1940s. It is no longer commercially available today. Structure and … Antihistamines for Allergies
Products Erythromycin is commercially available for peroral administration in tablet and granular form (Erythrocin / Erythrocin ES). This article refers to the drugs intended for ingestion. Erythromycin was first approved in the 1950s. Structure and properties Erythromycin is a natural substance produced by the bacterium (formerly: ). In oral medications, it is present as erythromycin … Erythromycin
Products Aprepitant is commercially available in the form of capsules (Emend). It has been approved in many countries since 2003. Structure and properties Aprepitant (C23H21F7N4O3, Mr = 534.4 g/mol) is a morpholine and triazol-3-one derivative. It exists as a white crystalline powder that is practically insoluble in water. For intravenous use, the more water-soluble prodrug … Aprepitant
Products Loratadine is commercially available in tablet form (Claritine, Claritine Pollen, generics). It has been approved in many countries since 1991. The active metabolite desloratadine is also available (Aerius, generics). Structure and properties Loratadine (C22H23ClN2O2, Mr = 382.9 g/mol) exists as a white crystalline powder that is practically insoluble in water. It is a prodrug … Loratadine
Products Mizolastine was commercially available in tablet form (Mizollen, 10 mg) and approved in many countries since 1996. The tablets are no longer available today. For example, fexofenadine (Telfast) or another 2nd-generation antihistamine can be used as an alternative. Structure and properties Mizolastine (C24H25FN6O, Mr = 432.5 g/mol) a piperidine and benzimidazole derivative. It is … Mizolastine
Products Mibefradil (Posicor tablets) was launched in many countries in 1996 and withdrawn from the market in 1998 because of potential interactions. It is no longer commercially available. Structure and properties Mibefradil (C29H38FN3O3, Mr = 495.6 g/mol) is a benzimidazole and a tetralol derivative. It is present in drugs as mibefradildihydrochloride. Effects Mibefradil (ATC C08CX01) … Mibefradil
Products Desloratadine is commercially available as 5 mg film-coated tablets and as a solution (Aerius, generics). It has been approved in many countries since 2001. The syrup was replaced in 2011 by a solution that is sugar- and dye-free. The concentration remains identical (0.5 mg/ml). The fixed combination with pseudoephedrine is not yet available in … Desloratadine
