Products Azilsartan has been approved in the United States and the EU in tablet form since 2011 (Edarbi). In many countries, it was registered in August 2012 as the 8th member of the sartan drug group. In 2014, a fixed combination with chlortalidone was approved (Edarbyclor). Structure Azilsartan (C25H20N4O5, Mr = 456.5 g/mol) is present … Azilsartan
Symptoms Rheumatoid arthritis is a chronic, inflammatory and systemic joint disease. It manifests as pain, symmetrically tense, achy, warm, and swollen joints, swelling, and morning stiffness that lasts for more than an hour. Initially, the hands, wrists, and feet are most affected, but later numerous other joints are also affected. Over time, deformities and rheumatoid … Rheumatoid Arthritis Causes and Treatment
Products Bextra film-coated tablets are no longer on the market in many countries. Approval was withdrawn in April 2005 because rare severe skin reactions had occurred during treatment (see below). Structure and properties Valdecoxib (C16H14N2O3S, Mr = 314.4 g/mol) is a phenylisoxazole and a benzenesulfonamide derivative. It has a V-shaped structure with which it binds … Valdecoxib
Products Firocoxib is commercially available as chewable tablets for dogs and as a paste for administration in horses. It has been approved in many countries since 2004. Structure and properties Firocoxib (C17H20O5S, Mr = 336.4 g/mol) is a furanone derivative. Like other COX-2 inhibitors, it has a V-shaped structure that allows binding to the Active … Firocoxib
Products COX-2 inhibitors (coxibe) are commercially available in the form of film-coated tablets and capsules. The first representatives from this group to be approved in many countries were celecoxib (Celebrex, USA: 1998) and rofecoxib (Vioxx, off label) in 1999. At that time, they rapidly developed into blockbuster drugs. However, due to adverse effects, several drugs … COX-2 Inhibitor
Products Cimicoxib is commercially available in the form of chewable tablets for dogs (Cimalgex). It has been approved in many countries since 2011. Structure and properties Cimicoxib (C16H13ClFN3O3S, Mr = 381.8 g/mol) is a chlorinated and fluorinated benzenesulfonamide and imidazole derivative. It has a V-shaped structure like other COX-2 inhibitors, which allows binding to the … Cimicoxib
Symptoms Gout is an inflammatory disease of the joints that manifests acutely in attacks of severe pain that worsens with pressure, touch, and movement. The joints are swollen with inflammation, and the skin is red and warm. Fever is observed. Gout often begins in the lower extremities and at the metatarsophalangeal joint (podagra). Urat crystals … Gout Causes and Treatment
Symptoms Pain is an unpleasant and subjective sensory and emotional experience associated with actual or potential tissue damage or described in terms of such damage. Acute pain may be accompanied by activation of the sympathetic nervous system, resulting in rapid heartbeat, deep breathing, hypertension, sweating, and nausea, among other symptoms. Pain has several components: Sensory/discriminative: … Acute Pain
Drug gastric protection Nonsteroidal anti-inflammatory drugs (NSAIDs) are commonly used for acute and long-term treatment of painful and inflammatory conditions. Active ingredients used include, for example, diclofenac, acetylsalicylic acid, ibuprofen, naproxen, and mefenamic acid. However, their use is limited by adverse effects that affect the upper digestive tract and are due to inhibition of prostaglandin … Stomach Protection
Products Nonsteroidal anti-inflammatory drugs (NSAIDs) are available in numerous dosage forms. These include film-coated tablets, tablets, sustained-release tablets, oral suspensions, oral granules, suppositories, NSAID eye drops, lozenges, emulsifying gels, and creams (selection). The first active ingredient from this group was salicylic acid, which was used medicinally in the 19th century in the form of the … NSAID
Products Etoricoxib is commercially available in the form of film-coated tablets (Arcoxia). It has been approved in many countries since 2009. Generics were registered in 2020. Structure and properties Etoricoxib (C18H15ClN2O2S, Mr = 358.8 g/mol) has a similar V-shaped structure to other COX-2 inhibitors. It is a dipyridinyl derivative with a methylsulfonyl group. Effects Etoricoxib … Etoricoxib
Symptoms The possible initial symptoms of colon cancer include: Change in bowel habits, diarrhea or constipation. Bleeding, blood in the stool, black colored stool. Frequent urge to defecate, discharge of small and thin portions. Abdominal pain, flatulence, cramps. Weight loss, weakness, anemia Because the cancer grows slowly, it takes years before clinical symptoms finally appear. … Colon Cancer: Causes and Treatment
