Products Dihydropyridines are commercially available in many countries in the form of film-coated tablets, sustained-release tablets, capsules, and injectables. Nifedipine from Bayer (Adalat) was the first active ingredient from this group to enter the market in the mid-1970s. Today, amlodipine (Norvasc, generics) is most commonly prescribed. Structure and properties The name 1,4-dihydropyridines is derived from … Dihydropyridine
Products Felodipine is commercially available in the form of sustained-release tablets. In addition to the original Plendil, generic versions are also available. It has been approved in many countries since 1988. Structure and properties Felodipine (C18H19Cl2NO4, Mr = 384.3 g/mol) is a dihydropyridine. It exists as a white to pale yellow crystalline powder that is … Felodipine
Products Nifedipine is commercially available in the form of sustained-release tablets (generics). It was first approved in the mid-1970s. Sales of the original Adalat were discontinued in many countries in 2019. Structure and properties Nifedipine (C17H18N2O6, Mr = 346.3 g/mol) is a dihydropyridine. It exists as a yellow crystalline powder that is practically insoluble in … Nifedipine: Drug Effects, Side Effects, Dosage and Uses
Effects Nifedipine is an active ingredient of the dihydropyridine group and has a relaxing effect on vascular smooth muscle. When used topically or orally, it dilates blood vessels, improves blood flow and thus wound healing, is anti-inflammatory, and relieves anal sphincter spasms. Dihydropyridines inhibit the influx of calcium into smooth muscle cells by inhibiting L-type … Nifedipine Cream for Anal Fissure
Products Isradipine is commercially available in capsule form (Lomir SRO). It has been approved in many countries since 1991. Structure and properties Isradipine (C19H21N3O5, Mr = 371.4 g/mol) is a racemate. It exists as a yellow crystalline powder that is practically insoluble in water. Effects Isradipine (ATC C08CA03) has antihypertensive properties. Its effects are due … Isradipine
Products Lercanidipine is commercially available in the form of film-coated tablets (Zanidip, Zanipress + enalapril). It has been approved in many countries since 2004. Generic versions were registered in 2014. Structure and properties Lercanidipine (C36H41N3O6, Mr = 611.7 g/mol) is a dihydropyridine. It is present in drugs as lercanidipine hydrochloride. The -enantiomer is primarily active. … Lercanidipine
Products Nimodipine is commercially available as an infusion solution and tablets (Nimotop). It has been approved in many countries since 1987. Structure and properties Nimodipine (C21H26N2O7, Mr = 418.4 g/mol) is a racemate. It exists as a pale yellow to yellow crystalline powder that is practically insoluble in water. Effects Nimodipine (ATC C08CA06) has cerebral … Nimodipine
Products Nitrendipine is commercially available in tablet form (Baypress / – mite). It was approved in many countries since 1985. In 2017, its distribution was discontinued. Structure and properties Nitrendipine (C18H20N2O6, Mr = 360.4 g/mol) is a dihydropyridine and a racemate. It exists as a yellow crystalline powder that is practically insoluble in water. The … Nitrendipine
Products Amlodipine is commercially available in tablet form (Norvasc, generic). It has been approved in many countries since 1990. Amlodipine is also combined fixed with the following agents: Aliskiren, atorvastatin, perindopril, telmisartan, valsartan, olmesartan, hydrochlorothiazide, and indapamide. Structure and properties Amlodipine (C20H25ClN2O5, Mr = 408.9 g/mol) has a chiral center and is a racemate. It … Amlodipine (Norvasc)
Symptoms In venous insufficiency, the normal return flow of venous blood to the heart is disturbed due to various causes. The following symptoms occur on the legs, especially the ankle and lower leg: Superficial venous dilatation: Varicose veins, spider veins, varicose veins. Pain and heaviness, tired legs Fluid retention, swelling, “water in the legs”. Calf … Chronic Venous Insufficiency
Products Lacidipine was commercially available in the form of film-coated tablets (Motens, off label). It was approved in many countries since 1992. Distribution was discontinued in 2016. Structure and properties Lacidipine (C26H33NO6, Mr = 455.5 g/mol) is a lipophilic dihydropyridine and structurally related to the precursor nifedipine. Effects Lacidipine (ATC C08CA09) is vasodilator and antihypertensive. … Lacidipine
Products Atenolol is commercially available in the form of film-coated tablets (Tenormin, generics). It has been approved in many countries since 1976 and is also combined fixed with chlortalidone (Tenoretic). Structure and properties Atenolol (C14H22N2O3, Mr = 266.3 g/mol) is a racemate. It exists as a white powder that is sparingly soluble in water. Effects … Atenolol
