Products Most sartans are commercially available as tablets or film-coated tablets. Losartan was the first agent approved in many countries in 1994 (Cosaar, USA: 1995, Cozaar). Sartans are often combined with hydrochlorothiazide fix. The name of the drug group is derived from the suffix -sartan of the active ingredients. The drugs are also called angiotensin … Sartans
Products Orexin receptor antagonists are commercially available in tablet form. The first agent in this group to be approved in the United States was suvorexant (Belsomra) in 2014. Lemborexant (Dayvigo) followed in 2019. Structure and properties Orexin receptor antagonists are characterized by a central ring structure to which heterocycles are attached on both sides. Effects … Orexin Receptor Antagonists
Definition Amines are organic molecules containing nitrogen (N) atoms bonded to carbon or hydrogen atoms. They are formally derived from ammonia, in which hydrogen atoms have been replaced by carbon atoms. Primary amines: 1 carbon atom Secondary amines: 2 carbon atoms Tertiary amines: 3 carbon atoms The functional group is called the amino group, for … Amines
Products Janus kinase inhibitors are commercially available in the form of tablets and capsules with different galenics. Structure and properties The structure of Janus kinase inhibitors is characterized by nitrogen heterocycles, which are often condensed. Effects The agents have selective immunosuppressive, anti-inflammatory, and antiproliferative properties. The effects are based on inhibition of Janus kinases (JAK). … Janus Kinase Inhibitors
Products Azole antifungals are approved in many countries for both topical and systemic treatment. They are available in numerous dosage forms-including creams, an oral gel, powders, sprays, tablets, capsules, injectables, vaginal creams, and vaginal tablets. The first azole antifungal came on the market in the 1950s. Structure and properties The name azole refers to heterocycles … Azole Antifungals
Products Alkaloids and their derivatives are contained as active ingredients in numerous medicines. They have been used medicinally for thousands of years, such as opium with morphine or coca leaves with cocaine. In 1805, a pure alkaloid was extracted for the first time by the German pharmacist Friedrich Sertürner with morphine. Structure and properties Alkaloids … Alkaloids
Products Serotonin receptor antagonists are commercially available in the form of film-coated tablets, melting tablets, soft capsules, as syrups, and as infusion/injection preparations. This article refers to the setrone (5-HT3 receptor antagonists), which are used as antiemetics. The first agent from this group to be approved in the United States was ondansetron (Zofran) in 1991, … Serotonin Antagonists (Setrone)
Definition Ethers are organic molecules with the general structure R1-O-R2, where R1 and R2 are identical for symmetrical ethers. The radicals can be aliphatic or aromatic. Cyclic ethers exist, such as tetrahydrofuran (THF). Ethers can be prepared using, for example, Williamson’s synthesis: R1-X + R2-O–Na+ R1-O-R2 + NaX X stands for halogens Nomenclature Trivial names … Ether
Products Disinfectants are commercially available in the form of sprays, as solutions, gels, soaps and as soaked swabs, among others. A distinction can be made between products intended for use on humans (skin, mucous membranes) and those intended for objects and surfaces. In addition to medical devices, medicinal products are also approved. These include, for … Disinfectant
Products Nitrogen is commercially available as a compressed gas in pressurized cylinders and as a liquid in cryogenic containers, among other products. Structure and properties Nitrogen (N, atomic mass: 14.0 u) is a colorless and odorless gas that is present in over 78% of air. It is a chemical element with atomic number 7 and … Nitrogen
Definition The best-known representative of the aromatics is benzene (benzenes), which consists of six carbon atoms arranged in a ring with angles of 120°. Benzene is usually drawn like a cylcoalkene, each with three alternating single and double bonds. However, benzene and the other aromatics do not belong to the alkenes and behave chemically differently. … Aromatics
