Products Lepirudin was commercially available as a lyophilizate (Refludan). It was approved in many countries in 1997 and is no longer on the market. Structure and properties Lepirudin is a derivative of hirudin from the leech. Effects Lepirudin (ATC B01AX03) is anticoagulant by direct inhibition of thrombin. Indications Heparin-associated thrombocytopenia (HAT) type II.
Products Thrombin inhibitors are commercially available in many countries in the form of infusion preparations and as capsules. The first oral thrombin inhibitor to be launched was ximelagatran (Exanta) in 2003. Due to its liver toxicity, sales had to be discontinued. Currently, the most widely used oral and direct thrombin inhibitor, dabigatran (Pradaxa), was approved … Thrombin Inhibitors
Products Bivalirudin was commercially available as a powder for preparation of a concentrate for solution for injection or infusion (Angiox). It was approved in many countries as of 2007. It has since become unavailable. Structure and properties Bivalirudin originated from hirudin, an anticoagulant substance found in leeches. Effects Bivalirudin (ATC B01AE06) has antithrombotic properties. Indications … Bivalirudin
Synonyms in a broader sense Phenprocoumon (active ingredient name) Coumarins Vitamin K antagonists (inhibitors) Anticoagulants Anticoagulant Side effects of Marcumar Side effects (so-called UAW’s, adverse drug reactions) and interactions with other drugs Among the most common undesirable effects of coumarin therapy are lighter bleeding with haematoma. These are usually harmless (2-5% of patients), so discontinuing … Side effects of Marcumar
When must Marcumar® not be given? In general, coumarins must not be administered during pregnancy, as they can cause severe damage both in the early stages of child development (“embryopathies”, third to eighth week of pregnancy) and in the later, usually less sensitive developmental stages (“fetopathies”, from the ninth week of pregnancy onwards). Alternatives to … When must Marcumar® not be given? | Side effects of Marcumar
