Menopause: Climacteric

Menopause usually occurs in women between the ages of 45 and 60. During this time, the body’s production of sex hormones decreases and the ability to reproduce recedes. At the same time, but also four to five years earlier, more or less pronounced complaints such as hot flashes, sweating and emotional changes can cause problems. … Menopause: Climacteric

Thyroid Disorders in Women

Overall, thyroid disorders affect more women than men in the population. One reason for this is due to the major hormonal fluctuations during a woman’s life. Pregnancy and menopause, as well as hormone use during contraception and hormone replacement therapy, expose the female body to changing hormonal influences. Since all hormones in the body, including … Thyroid Disorders in Women

Anastrozole

Products Anastrozole is commercially available in the form of film-coated tablets (Arimidex, generic). It has been approved in many countries since 1996. Structure and properties Anastrozole (C17H19N5, Mr = 293.4 g/mol) exists as a white powder that is very sparingly soluble in water. It is a triazole derivative with a non-steroidal structure. Effects Anastrozole (ATC … Anastrozole

Androgens: Steroid Hormones

Products Androgens are commercially available as oral tablets and capsules, transdermal gels and transdermal patches, and injectables, among others. Testosterone was first isolated in the 1930s. Structure and properties Androgens generally have a steroidal structure and are related to testosterone. They are steroid hormones that are often present as esters in drugs. Effects Androgens (ATC … Androgens: Steroid Hormones

Estradiol

Products Estradiol is commercially available in tablet, transdermal patch, transdermal gel, vaginal ring, and vaginal tablet forms, among others. It is also combined fixed with progestogens. Structure and properties Estradiol (C18H24O2, Mr = Mr = 272.4 g/mol) exists as a white crystalline powder that is practically insoluble in water. Synthetic estradiol is bioidentical with human … Estradiol

GnRH Analogs

Products GnRH analogs are commercially available in many countries in the form of injectables, implants, and nasal sprays, among others. The first agent to be approved was goserelin (Zoladex) in 1990. Structure and properties GnRH analogs are synthetically produced derivatives of gonadotropin-releasing hormone (GnRH, LHRH) produced in the hypothalamus. GnRH is a decapeptide and has … GnRH Analogs

Toremifene

Products Toremifene is commercially available in tablet form (Fareston). It was approved in many countries in 1996 and went off the market in 2012. Structure and properties Toremifene (C26H28ClNO, 405.96 g/mol) Effects Toremifene (ATC L02BA02) is antiestrogenic. Indications Local unresectable, locally recurrent, or metastatic postmenopausal breast carcinoma (breast cancer). Contraindications For complete precautions, see the … Toremifene

Triptans: Drug Effects, Side Effects, Dosage and Uses

Products Triptans are mainly taken in the form of film-coated tablets and melting tablets. Some are also available as subcutaneous injectable solutions and nasal sprays. Suppositories are no longer commercially available in many countries. Sumatriptan (Imigran) was the first agent in this group to be approved in the United States in 1992 and in many … Triptans: Drug Effects, Side Effects, Dosage and Uses

Triptorelin

Products Triptorelin is commercially available as an injectable. It has been approved in many countries since 1995. Structure and properties Triptorelin is a more potent derivative of gonadotropin-releasing hormone (GnRH). At position 6, the amino acid glycine has been replaced by D-tryptophan. It is a decapeptide. GnRH: Pyr-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly. Triptorelin: Pyr-His-Trp-Ser-Tyr-D-Trp-Leu-Arg-Pro-Gly Effects Triptorelin (ATC L02AE04) is … Triptorelin

Citalopram: Drug Effects, Side Effects, Dosage and Uses

Products Clomiphene was commercially available in tablet form (Serophene, Clomid). It was approved in many countries since 1967 and is currently no longer available. Drugs containing the active ingredient can be imported from abroad. Structure and properties Clomiphene (C26H28ClNO, Mr = 405.95 g/mol) is a nonsteroidal triphenylethylene derivative that exists as an unequal mixture of … Citalopram: Drug Effects, Side Effects, Dosage and Uses