Products Olmesartan is commercially available in the form of film-coated tablets (Olmetec, Votum, fixed combinations with amlodipine and hydrochlorothiazide). It has been approved in many countries since 2005. Generics were registered in 2016 and went on sale in 2017. Structure and properties Olmesartan is present in drugs as olmesartan medoxomil (C29H30N6O6, Mr = 558.6 g/mol), … Olmesartan
Products Chickenpox vaccine is commercially available as an injectable in many countries (e.g., Varivax). It can also be combined fixed with the MMR vaccine (= MMRV vaccine). Structure and properties This is a live attenuated vaccine containing varicella-zoster virus of the OKA/Merck strain grown in human cells. This strain was developed in Japan in the … Chickenpox Vaccination
Kasabach-Merritt syndrome is a vascular tumor disorder associated with platelet-consuming coagulopathy and thrombocytopenia. Treatment of the disease has been experimental to date. Interferons and corticosteroids have shown promise in many cases. What is Kasabach-Merritt syndrome? Kasabach-Merritt syndrome is also called hemangioma–thrombocytopenia syndrome and corresponds to a rare blood disorder. Hemangiomas and a coagulopathy with platelet … Kasabach-Merritt Syndrome: Causes, Symptoms & Treatment
Bisphosphonate-associated bone necrosis is necrosis of bone that occurs as a result of treatment with bisphosphonates. In the majority of cases, bone necrosis occurs after treatment by a dentist or orthodontist after bisphosphonates have been used. Therefore, bisphosphonate-associated bone necrosis of the jaw is particularly common. In addition, spontaneous bisphosphonate-associated bone necrosis is possible. What … Bisphosphonate-associated Bone Necrosis: Causes, Symptoms & Treatment
Symptoms Within minutes to hours or days, a red and itchy to burning rash appears after exposure to UV radiation (sunlight, solarium). It manifests itself in numerous forms, including papules, vesicles, papulovesicles, small blisters, as eczema or plaque, and is therefore called polymorphic. However, the same expression is usually observed in individual patients. Most affected … Polymorphous Light Dermatosis
Products and approval Fingolimod is commercially available in capsule form (Gilenya) and has been approved in many countries since 2011. First generic products were registered in 2020 and entered the market in 2021. Fingolimod was the first specific multiple sclerosis drug to be administered orally, rather than being injected subcutaneously or as an infusion. In … Fingolimod
Products Pembrolizumab was approved as an infusion product in the United States in 2014 and in the EU and many countries in 2015 (Keytruda). Structure and properties Pembrolizumab is a humanized monoclonal antibody. It is an IgG4-κ immunoglobulin with a molecular weight of approximately 149 kDa. Effects Pembrolizumab (ATC L01XC18) has antitumor and immunomodulatory properties. … Pembrolizumab
Symptoms Local skin reactions such as itching, inflammation, redness, and blistering occur acutely, especially at the sites of contact with the trigger. In the chronic stage, dry, scaly and cracked skin is often observed, e.g. in the form of chronic hand eczema. Affected areas include the hands, abdomen and earlobes. The rash can also appear … Metal Allergy
Products Tofacitinib was approved in the United States in November 2012, in many countries in 2013, and in the EU in 2017 in film-coated tablet form (Xeljanz). The European Medicines Agency initially rejected the approval in April 2013. However, baricitinib was approved. In the United States, additional sustained-release film-coated tablets are available that are taken … Tofacitinib
Products Rabies vaccine is commercially available as a solution for injection (Rabipur, Rabies Vaccine Mérieux). This article refers to active immunization. Structure and properties The vaccine contains inactivated rabies virus of the Flury LEP or WISTAR PM/WI 38-1503-3M strain. Effects Rabies vaccine (ATC J07BG01) results in the formation of neutralizing antibodies and thus immunity to … Rabies Vaccination (Active Immunization)
Symptoms Oral mucositis manifests as redness, swelling, pain, a burning sensation, aphthae, a white to yellowish coating, sores, ulceration, bleeding, and bad breath, among other symptoms. The tongue and gums may also be affected. The discomfort may increase in association with eating. Sores can be so painful that food intake is limited, which can lead … Oral Mucositis
Symptoms Oral thrush is an infection of the mouth and throat with Candida fungi. Different manifestations are distinguished. The actual oral thrush is usually called acute pseudomembranous candidiasis. The leading symptom is the white to yellowish, small-spotted, partially intermingled coating of the mucous membranes in the mouth and throat area. It consists of epithelial cells, … Oral Thrush
