Symptoms Mouth corner rhagades manifest as inflamed tears in the area of the corners of the mouth. The symptoms are often bilateral and and often involve the adjacent skin. Other symptoms include redness, scaling, pain, itching, crusting and dehydration. Mouth cracks are uncomfortable, bothersome and often slow to heal. Causes Typical causes and risk factors … Corner of the Mouth Cracks
Symptoms Nummular eczema (from Latin , coin) is an inflammatory skin disease that manifests itself in sharply defined, coin-shaped rashes that primarily affect the extensor sides of the legs, arms, and trunk. The areas are weeping, inflamed (reddened), and may become dry, crusted, and itchy. Unlike cutaneous fungus, the lesions are filled in and do … Nummular Eczema
Symptoms Condylomata acuminata is a benign infectious disease of the skin and mucous membranes caused by human papillomavirus. It manifests itself in benign warts, called genital warts, which appear in the genital and/or anal areas. However, such warts appear in less than 1% of people infected with HPV. In men, the tip of the penis … Condylomata Acuminata
Symptoms Toxoplasmosis is usually asymptomatic and unnoticed if the immune status is normal. It may manifest as flu-like symptoms such as muscle and joint pain, sore throat, swollen lymph nodes, headache, fever, and fatigue. The infection leads to immunity. If the immune system is weakened, such as observed in HIV infection and when taking immunosuppressants … Toxoplasmosis Causes and Treatment
Symptoms Irritant contact dermatitis is a common inflammatory condition of the skin. It often occurs on the hands and manifests in the following possible signs and symptoms: Redness Swellings Dry skin Scaling, often between the fingers Itching, burning, pain, tightness, tingling. Increased sensitivity, for example, to alcohol in disinfectants. Skin thickening Painful tears Crusts Erosions … Irritant Contact Dermatitis
Products Methotrexate is commercially available as a solution for parenteral use and in tablet form. See also under methotrexate prefilled syringe (low-dose). Structure and properties Methotrexate (C20H22N8O5, Mr = 454.44 g/mol) is a dicarboxylic acid that exists as a yellow to orange crystalline powder that is virtually insoluble in water. Methotrexate was developed as a … Methotrexate: Drug Effects, Side Effects, Dosage and Uses
Products Ciclosporin is commercially available as capsules, a drinkable solution, and an infusion concentrate (Sandimmune, Sandimmune Neoral, generics). It has been approved in many countries since 1995. Neoral is the microemulsion formulation that has more stable bioavailability than traditional Sandimmune. In 2016, ciclosporin eye drops were approved (see there). Structure and properties Ciclosporin (C62H111N11O12, Mr … Ciclosporin
Products Ciclosporin eye drops were approved in the EU in 2015 and in many countries in 2016 (Ikervis). They have been registered in the United States since 2009 (Restasis). Structure and properties Ciclosporin (C62H111N11O12, Mr = 1203 g/mol) exists as a white powder that is practically insoluble in water. It is extracted from the mushroom … Ciclosporin Eye Drops
Symptoms Actinic keratosis is a skin disease that manifests itself in various forms. Pink or brown, scaly, highly keratinized patches or papules often form on a reddened base, with sizes ranging from millimeters to centimeters. The lesions can occur all over the body, but usually affect sun-exposed areas such as the head, bald head, ears, … Actinic Keratosis Treatment
Background That grapefruit juice can cause drug-drug interactions was discovered by chance in a clinical trial in 1989 and confirmed in an experiment by the same research group in 1991 (Bailey et al, 1989, 1991). This showed that simultaneous ingestion of grapefruit juice with the calcium channel blocker felodipine significantly increases the bioavailability of felodipine. … Interactions with Grapefruit Juice
Products Janus kinase inhibitors are commercially available in the form of tablets and capsules with different galenics. Structure and properties The structure of Janus kinase inhibitors is characterized by nitrogen heterocycles, which are often condensed. Effects The agents have selective immunosuppressive, anti-inflammatory, and antiproliferative properties. The effects are based on inhibition of Janus kinases (JAK). … Janus Kinase Inhibitors
Products BNT162b2 from German biotechnology company BioNTech and Pfizer was approved in many countries on December 19, 2020, as the first representative of mRNA vaccines and Covid-19 vaccines (Comirnaty, frozen suspension). The vaccine was studied in 2020 in a large Phase III trial with more than 44,000 participants. Switzerland was the first country in which … BNT162b2 (Tozinameran)
