Products Daptomycin is commercially available as a powder for the preparation of a solution for injection or infusion (Cubicin). It has been approved in many countries since 2007. Generic versions are registered. Structure and properties Daptomycin (C72H101N17O26, Mr = 1620.7 g/mol) is a cyclic lipopeptide that is obtained as a fermentation product from . It … Daptomycin
Products Gemcitabine is commercially available as a lyophilizate for the preparation of an infusion solution (Gemzar, generics). It has been approved in many countries since 1997. Structure and properties Gemcitabine (C9H11F2N3O4, Mr = 263.2 g/mol) is present in drugs as gemcitabine hydrochloride, a white substance that is soluble in water. The pyrimidine gemcitabine is a … Gemcitabine
Products Alemtuzumab is commercially available as a concentrate for the preparation of an infusion solution (Lemtrada). It was approved in 2014. Alemtuzumab was originally approved for leukemia treatment and marketed as MabCampath (approved in 2001). Structure and properties Alemtuzumab is a humanized IgG1 kappa monoclonal antibody to CD52 produced by biotechnological methods. It has a … Alemtuzumab
Products Cetuximab is commercially available as an infusion solution (Erbitux). It has been approved in many countries since 2003. Structure and properties Cetuximab is a recombinant chimeric (human/mouse) IgG1 monoclonal antibody. It is produced by biotechnological methods. Effects Cetuximab (ATC L01XC06) has antitumor and antiangiogenic properties. It is a specific antibody against the epidermal growth … Cetuximab
Products Hydromorphone is commercially available as sustained-release tablets, sustained-release capsules, capsules, solution for injection, solution for infusion, and drops (e.g., Palladon, Jurnista, Hydromorphoni HCl Streuli). It has been approved in many countries since 1996. Structure and properties Hydromorphone (C17H19NO3, Mr = 285.3 g/mol) is a semisynthetic, hydrogenated and oxidized morphine derivative. It is present in … Hydromorphone
Products Cabazitaxel is released as a concentrate for the preparation of an infusion solution. It has been approved in many countries since 2011 (Jevtana). Structure and properties Cabazitaxel (C45H57NO14, Mr = 835.9 g/mol) is a taxane semisynthetically derived from a constituent of yew needles. It is structurally closely related to docetaxel, which is itself a … Cabazitaxel
Products Reslizumab was approved in the United States and EU in 2016 and in many countries in 2017 as a concentrate for the preparation of an infusion solution (Cinqaero). Structure and properties Reslizumab is a humanized IgG4/κ monoclonal antibody produced by biotechnological methods. The molecular mass is approximately 147 kDa. Effects Reslizumab (ATC R03DX08) binds … Reslizumab
Products Andexanet alfa was approved in the United States in 2018, in the EU in 2019, and in many countries in 2020 as a powder for the preparation of an infusion solution (Ondexxya). Structure and properties Andexanet alfa is a recombinant, modified, and enzymatically inactive factor Xa. The drug is produced by biotechnological methods. Effects … Andexanet Alfa
Products Vedolizumab was approved in many countries in 2015 as a powder for a concentrate for the preparation of an infusion solution (Entyvio). In 2020, a prefilled pen and prefilled syringe were also registered. Structure and properties Vedolizumab is a humanized IgG1 monoclonal antibody with a molecular mass of 147 kDa. Effects Vedolizumab (ATC L04AA33) … Vedolizumab
Products Decitabine is commercially available as a lyophilizate for the preparation of a concentrate for infusion solution (Dacogen). It has been approved in many countries and in the EU since 2012. Structure and properties Decitabine (C8H12N4O4, Mr = 228.2 g/mol) or 5-aza-2′-deoxycytidine is an analog of cytidine deoxynucleoside and differs from deoxycytidine by a C … Decitabine
Products Defibrotide was approved in many countries in 2020 as a concentrate for the preparation of an infusion solution (Defitelio). Structure and properties Defibrotide is a mixture of single-stranded oligonucleotides derived from porcine intestinal mucosa. Effects Defibrotide (ATC B01AX01) has antithrombotic, fibrinolytic, antiadhesive, and anti-inflammatory properties. Indications For the treatment of severe hepatic veno-occlusive disease … Defibrotide
Products Colistimethate is commercially available as a powder for the preparation of a solution for a nebulizer and as a powder for the preparation of an infusion solution for a nebulizer. It has been approved in many countries since 2000. Structure and properties Colistimethate sodium is prepared from colistin by reaction with formaldehyde and sodium … Colistimethate
