Products Octreotide is commercially available as an injectable (Sandostatin, Sandostatin LAR, generics). It has been approved in many countries since 1988. Structure and properties Octreotide is a synthetic octapeptide derivative of the hormone somatostatin. It is present in the drug as octreotide acetate and has the following structure: D-Phe-Cys-Phe-D-Trp-Lys-Thr-Cys-Thr-ol, xCH3COOH (x = 1.4 to 2.5). … Octreotide
Products Golimumab is commercially available as a solution for injection (Simponi). It was approved in many countries in 2010. Structure and properties Golimumab (Mr = 150 kDa) is a human IgG1κ-monoclonal antibody. Effects Golimumab (ATC L04AB06) has selective immunosuppressive and anti-inflammatory properties. The effects are based on binding to the soluble and membrane-bound proinflammatory cytokine … Golimumab
Products Filgrastim is commercially available as a solution for injection in vials and prefilled syringes (Neupogen, biosimilars). It has been approved in many countries since 1991. Structure and properties Filgrastim is a protein of 175 amino acids produced by biotechnology. The sequence corresponds to human granulocyte colony-stimulating factor (G-CSF, Mr = 18,800 Da) with the … Filgrastim
Products Valproic acid is commercially available as tablets, mini-tablets (minipacks), capsules, injectable, syrup, and solution (Depakine, generic). It has been approved in many countries since 1972. Structure and properties Valproic acid (C8H16O2, Mr = 144.2 g/mol) or 2-propylpentanoic acid is a colorless to slightly yellowish, clear, and slightly viscous liquid that is very slightly soluble … Valproic Acid: Drug Effects, Side Effects, Dosage and Uses
Products Darbepoetin alfa is commercially available as an injectable (Aranesp). It has been approved in many countries since 2002. Structure and properties Darbepoetin alfa is a recombinant glycoprotein produced by biotechnological methods. It consists of 165 amino acids and has the same sequence as natural erythropoietin (EPO), which is formed in the kidney, except for … Darbepoetin Alfa
Products Ondansetron is commercially available in the form of film-coated tablets, meltable tablets (lingual tablets), as a syrup, and as an infusion/injection preparation. In addition to the original Zofran, generic versions are also available. Ondansetron was introduced in 1991 as the first active ingredient from the group of 5-HT3 receptor antagonists was approved. Structure and … Ondansetron
Products Cetrorelix is commercially available as a powder and solvent for the preparation of a solution for injection (Cetrotide). It has been approved in many countries since 2003. Structure and properties Cetrorelix acetate is present in drugs as cetrorelix acetate. It is a decapeptide and a derivative of gonadotropin-releasing hormone (GnRH) produced by the hypothalamus, … Cetrorelix
Products Ketorolac commercially available in the form of film-coated tablets, as a solution for injection (Tora-Dol), and as eye drops (Acular, generic). It has been approved in many countries since 1992. Structure and properties Ketorolac (C15H13NO3, Mr = 255.7 g/mol) is present in drugs in the form of the salt ketorolactrometamol (= ketorolactromethamine), see also … Ketorolac
Products Hydromorphone is commercially available as sustained-release tablets, sustained-release capsules, capsules, solution for injection, solution for infusion, and drops (e.g., Palladon, Jurnista, Hydromorphoni HCl Streuli). It has been approved in many countries since 1996. Structure and properties Hydromorphone (C17H19NO3, Mr = 285.3 g/mol) is a semisynthetic, hydrogenated and oxidized morphine derivative. It is present in … Hydromorphone
Products Pegvisomant is commercially available as a powder and solvent for the preparation of a solution for injection (Somavert). It has been approved in many countries since 2005. Structure and properties Pegvisomant is a derivative of human growth hormone produced by biotechnological methods. It consists of 191 amino acids and is pegylated at several sites. … Pegvisomant
Products Metamizole is commercially available as drops, tablets, suppositories, and injectables (Minalgin, Novalgin, Novaminsulfon Sintetica, generics). It has been used medicinally since the 1920s. Structure and properties Metamizole (C13H17N3O4S, Mr = 311.4 g/mol) is present in drugs as metamizole sodium. This is the sodium salt and monohydrate of the active ingredient. Metamizole sodium is a … Metamizole: Drug Effects, Side Effects, Dosage and Uses
Products Pegaspargase is commercially available as an injectable (Oncaspar). The drug was approved in the United States in 2006, in the EU in 2016, and in many countries in 2017. Structure and properties Pegaspargase (PEG-L-asparaginase) is the pegylated enzyme L-asparaginase. The PEG units are covalently attached to the enzyme. Effects Pegaspargase (ATC L01XX24) has antileukemic … Pegaspargases
