Products Ocrelizumab was approved in many countries and in the United States in 2017 and in the EU in 2018 as an infusion concentrate (Ocrevus). Structure and properties Ocrelizumab is a humanized IgG1 monoclonal antibody with a molecular mass of 145 kDa. It is produced by biotechnological methods. Ocrelizumab is the successor agent to rituximab … Ocrelizumab
Products Reteplase was marketed as an injectable (Rapilysin). The drug was approved in many countries in 1996 and withdrawn from the market in 2013. Structure and properties Reteplase is derivative of tissue-specific plasminogen activator (t-PA). It is a serine protease containing 355 of the 527 amino acids of native t-PA. The protein is produced by … Reteplase
Products Susoctocog alfa is commercially available as a powder and solvent for solution for injection (Obizur). It was approved in the United States in 2014, in the EU in 2015, and in many countries in 2016. Structure and properties Susoctocog alfa is a recombinant derivative of porcine blood clotting factor VIII lacking the B domain. … Susoctocog Alfa
Products Suxamethonium chloride is commercially available as a solution for injection (lysthenone, succinoline). It was introduced in the 1950s and has been approved in many countries since 1954. Suxamethonium chloride is also known as succinylcholine or succinylcholine chloride, especially in English. In jargon, it is also called Suxi or Sux. Structure and properties Suxamethonium chloride … Suxamethonium Chloride
Symptoms Symptoms of Covid-19 include (selection): Fever Cough (irritating cough or with sputum) Respiratory disorders, shortness of breath, shortness of breath. Feeling sick, fatigue Cold symptoms: runny nose, stuffy nose, sore throat. Pain in the limbs, muscle and joint pain. Gastrointestinal complaints: Diarrhea, nausea, vomiting, abdominal pain. Nervous system: impairment of the sense of smell … COVID-19
Products Damoctocog alfa pegol was approved as a preparation for solution for injection in the United States and the EU in 2018 and in many countries in 2019 (Jivi). Structure and properties Damoctocog alfa pegol is a pegylated, B-domain-deleted, conjugated, recombinant blood coagulation factor VIII (rFVIII). The molecular mass is approximately 234 kDa. The drug … Damoctocog Alfa Pegol
Products Neuraminidase inhibitors are commercially available in the form of capsules, powder for oral suspension, powder inhalers, and injectables. The first agents to be approved were zanamivir (Relenza) in 1999, followed by oseltamivir (Tamiflu). Laninamivir (Inavir) was released in Japan in 2010 and Peramivir (Rapivab) in the USA in 2014. The public is most familiar … Neuraminidase Inhibitor
Products Dexmedetomidine is commercially available as a concentrate for the preparation of an infusion solution (Dexdor). It was approved in many countries in 2012. Structure and properties Dexmedetomidine (C13H16N2, Mr = 200.3 g/mol) is an imidazole derivative and the -enantiomer of medetomidine. It is structurally closely related to detomidine and is present in drugs as … Dexmedetomidine
Products APN01 is in clinical development at Apeiron Biologics. Structure and properties APN01 is a recombinant, soluble, and human angiotensin-converting enzyme 2 (ACE2). Effects APN01 functions as a false receptor for the coronavirus SARS-CoV-2, the causative agent of the viral disease Covid-19. SARS-CoV-2 uses ACE2 for attachment and entry into host cells. APN01 is a … APN01 (Recombinant ACE2)
Products Abatacept is commercially available as an injection and infusion preparation (Orencia). It was approved in the United States in 2005 and in the EU and many countries in 2007. Structure and properties Abatacept is a recombinant fusion protein with the following components: Extracellular domain of CTLA-4 (cytotoxic T-lymphocyte-associated protein 4). Modified Fc domain of … Abatacept
Products Carmustine is commercially available in many countries as a powder and solvent for the preparation of an infusion solution (BiCNU). An implant is also available in some countries (Gliadel). Structure and properties Carmustine (C5H9Cl2N3O2, Mr = 214.0 g/mol) belongs to the nitrosoureas. It exists as a yellowish, granular powder that is very sparingly soluble … Carmustine
Products Thiopental is commercially available as an injectable (generic). It has been approved in many countries since 1947. Structure and properties Thiopental (C11H18N2O2S, Mr = 242.3 g/mol) is present in the drug as thiopental sodium, a yellowish white, hygroscopic powder that is readily soluble in water. It is a lipophilic thiobarbiturate identical to pentobarbital except … Thiopental
