Products Caffeine citrate solution was newly approved in many countries in 2016 (Peyona). It was available earlier in other countries. Structure and properties Caffeine (C8H10N4O2, Mr = 194.2 g/mol) exists as a white crystalline powder or as white silk-like crystals and is sparingly soluble in water. The substance sublimes readily. Citric acid monohydrate (C6H8O7 – … Caffeine Citrate Solution
Products Octocog alfa is commercially available as an injectable. It has been approved in many countries since 2004. Structure and properties Octocog alfa is the recombinant blood clotting factor VIII produced by biotechnological methods. In the past, it was also obtained from plasma, but this posed a risk for the transmission of infectious diseases. Octocog … Octocog Alfa
Products Carfilzomib was approved in many countries in 2015 as a powder for the preparation of an infusion solution (Kyprolis). Structure and properties Carfilzomib (C40H57N5O7, Mr = 719.9 g/mol) exists as a crystalline substance that is practically insoluble in water. It is a peptide derivative, a tetrapeptide epoxyketone. Epoxyketones are derivatives of epoxomicin, a natural … Carfilzomib
Products Carboplatin is commercially available as an infusion solution (paraplatin, generic). It has been approved in many countries since 1986. Structure and properties Carboplatin (C6H12N2O4Pt, Mr = 371.3 g/mol) is a platinum compound. It exists as a colorless crystalline powder that is sparingly soluble in water. Carboplatin is structurally related to cisplatin, the first platinum … Carboplatin
Products TNF-α inhibitors are commercially available as injectable and infusion preparations. Infliximab (Remicade) was the first agent from this group to be approved in 1998, and in many countries in 1999. Biosimilars of some representatives are now available. Others will follow in the next few years. This article refers to biologics. Small molecules can also … TNF-Α Inhibitors
Products Amantadine is commercially available as film-coated tablets, capsules, and an infusion solution (Symmetrel, PK-Merz). It has been approved in many countries since 1966. Structure and properties Amantadine (C10H17N, Mr = 151.2 g/mol) is present in drugs as amantadine sulfate or amantadine hydrochloride. Amantadine hydrochloride is a white crystalline powder that is readily soluble in … Amantadine
Products Iron is available in the form of tablets, capsules, chewable tablets, drops, as a syrup, direct granules and as a solution for injection, among others (selection). These are approved drugs and dietary supplements. It is also combined with folic acid, with vitamin C and with other vitamins and minerals fix. Some dosage forms are … Iron
Products In many countries, injection solutions containing ferric carboxymaltose (Ferinject, 2007), ferrous sucrose (Venofer, 1949), ferumoxytol (Rienso, 2012), and ferric derisomaltose (ferric isomaltoside, Monofer, 2019) are commercially available. In other countries, other products with different compositions are available, for example, ferrous sodium gluconate. Iron dextrans are rarely used anymore because of the risk for severe … Iron Infusions
Products Ferric maltol is commercially available in the form of hard capsules (Feraccru, some countries: Accrufer). It was approved in the EU in 2016 and in many countries in 2017. Structure and properties Ferric maltol contains ferric ions in a complex with three molecules of maltol (ferric trimaltol). Due to the complexation, iron is better … Iron Maltol
Products Olaratumab was approved in the United States and EU in 2016 and in many countries in 2017 as a concentrate for the preparation of an infusion solution (Lartruvo). Structure and properties Olaratumab is a human IgG1 monoclonal antibody that binds to PDGFRα. It is produced by biotechnological methods and has a molecular weight of … Olaratumab
Products Inotuzumab ozogamicin was approved in many countries, in the EU, and in the United States in 2017 as a powder for a concentrate for the preparation of an infusion solution (Besponsa). See also under gemtuzumab ozogamicin. Structure and properties Inotuzumab ozogamicin is an antibody-drug conjugate directed against CD22. Inotuzumab is a humanized lgG4 monoclonal … Inotuzumab Ozogamicin
Products For ALS treatment, edaravone was approved in Japan in 2015 (Radicut) and in the United States in 2017 as an infusion product (Radicava). In the EU, edaravone has orphan drug status. In many countries, the drug has been registered since 2019. Structure and properties Edaravone (C10H10N2O, Mr = 174.2 g/mol) is a substituted 2-pyrazolin-5-one. … Edaravon
