How metformin works Metformin is a blood sugar-lowering drug. Its exact action, as well as the side effects of metformin, result from a variety of effects that the drug exerts in the body: After a carbohydrate-rich meal, the pancreas secretes the hormone insulin to keep blood glucose levels within the normal range. The sugars contained … Metformin: Effects, Areas of Application, Side Effects
Products Acarbose is commercially available in tablet form (Glucobay). It is usually combined with other agents such as metformin, insulin, or sulfonylureas to enhance the antidiabetic effect. Acarbose has been approved in many countries since 1986. Structure and properties Acarbose (C25H43NO18, Mr = 645.60 g/mol) is a pseudotetrasaccharide obtained from the bacterium by fermentation. It … Acarbose Effects and Side Effects
Products The first agent in the GLP-1 receptor agonist group to be approved was exenatide (Byetta) in the United States in 2005 and in many countries and the EU in 2006. In the meantime, several other drugs have been registered (see below). These drugs are also known as incretin mimetics. They are commercially available as … GLP-1 Receptor Agonists
Symptoms The possible acute symptoms of type 2 diabetes include: Thirst (polydipsia) and hunger (polyphagia). Increased urination (polyuria). Visual disturbances Weight loss Fatigue, exhaustion, declining performance. Poor wound healing, infectious diseases. Skin lesions, itching Acute complications: Hyperacidity (ketoacidosis), hyperosmolar hyperglycemic syndrome. Untreated diabetes is far from harmless and can lead in the longer term to … Diabetes Mellitus Type 2: Causes and Treatment
Products Saxagliptin is commercially available in the form of film-coated tablets (Onglyza). It was approved in many countries after sitagliptin (Januvia) and vildagliptin (Galvus) as the 3rd active ingredient from the gliptins group in February 2010. Since 2012, two additional combination products with metformin have been registered (Duoglyze, Kombiglyze XR). Kombiglyze XR entered the market … Saxagliptin
Effects Antiadiposita differ in their effects. They inhibit appetite or increase satiety, reduce the absorption of food components in the intestine or promote their utilization, increase energy metabolism and degrading metabolic processes. The ideal slimming agent would enable rapid, high and stable weight loss and at the same time be very well tolerated and applicable … Slimming Products
Products Tafenoquine was approved in the United States in 2018 in tablet form (Krintafel, Arakoda). Structure and properties Tafenoquine (C24H28F3N3O3, Mr = 463.5 g/mol) is an 8-aminoquinoline derivative present in the drug as tafenoquine succinate. It is a derivative of primaquine. The drug was first synthesized in 1978 at the Walter Reed Army Institute of … Tafenoquine
Stem plant Fabaceae, true geissraute. Medicinal drug Galegae herba – goat’s rue herb. Ingredients Guanidine derivatives: galegine (cf. metformin). Flavonoids Tannins Effects Blood sugar lowering Indications for use In folk medicine as an antidiabetic. Commission E gives a negative evaluation of its use. Dosage The use is not recommended. Adverse effects Hypoglycemia, possibly poisoning.
Products Empagliflozin is commercially available in the form of film-coated tablets. It was approved in the EU, the United States, and many countries in 2014 (Jardiance). Empagliflozin is also combined fixed with metformin (Jardiance Met) as well as with linagliptin (Glyxambi). Trijardy XR is a fixed combination of empagliflozin, linagliptin, and metformin. Structure and properties … Empagliflozin
Products Metformin is commercially available in many countries in the form of film-coated tablets and has been available since 1960. In addition to the original Glucophage, numerous generics are available today. Metformin is often combined with various other antidiabetic drugs fix. It has been used medically since 1957. Other antidiabetic biguanides such as phenformin and … Metformin: Drug Effects, Side Effects, Dosage and Uses
Products Repaglinide is commercially available in tablet form (NovoNorm, generic). It was approved in many countries in 1999. Structure and properties Repaglinide (C27H36N2O4, Mr = 452.6 g/mol) is a meglitinide and carbamoylmethylbenzoic acid derivative without sulfonylurea structure. It is a white, odorless powder that is practically insoluble in water due to its lipophilicity. In drugs, … Repaglinide
Products Glibenclamide is commercially available in tablet form (Daonil, generics). It has been approved in many countries since 1970 and is also used in fixed combination with metformin (Glucovance). Structure and properties Glibenclamide (C23H28ClN3O5S, Mr = 494.0 g/mol) is a sulfonylurea. It exists as a white crystalline powder that is practically insoluble in water. Effects … Glibenclamide
