Products Ketazolam is commercially available in capsule form (Solatran). It has been approved in many countries since 1980. Structure and properties Ketazolam (C20H17ClN2O3, Mr = 368.8 g/mol) structurally belongs to the 1,4-benzodiazepines. Effects Ketazolam (ATC N05BA10) has antianxiety, depressant, muscle relaxant, and anticonvulsant properties. The effects are due to binding to GABA-A receptors and enhancement … Ketazolam
Products Cannabinoid receptor antagonists are no longer on the market in many countries. Rimonabant (Acomplia) was withdrawn from the market in 2008 because it can cause psychiatric disorders, particularly depression. Effects Cannabinoid receptor antagonists have appetite suppressant, lipid-lowering, antidiabetic, analgesic (antiallodynic, antinociceptive), and anti-inflammatory properties. The effects of cannabinoid receptor antagonists are largely opposite to … Cannabinoid Receptor Antagonists
Products Eszopiclone is commercially available in the United States in the form of film-coated tablets (Lunesta). The drug is not registered in many countries. In contrast, the racemate zopiclone (Imovane) is on the market. Structure and properties Eszopiclone (C17H17ClN6O3, Mr = 388.8 g/mol) is the -enantiomer of zopiclone. It belongs to the cyclopyrrolones. Eszopiclone exists … Eszopiclone
Products Clomethiazole is commercially available in capsule form and as a mixture (Distraneurin, UK: Heminevrin). It was developed at Roche in the 1930s. Structure and properties Clomethiazole (C6H8ClNS, Mr = 161.65 g/mol) is a chlorinated and methylated thiazole derivative. The compound is related to the thiazole moiety of vitamin B1 (thiamine). Effects Clomethiazole (ATC N05CM02) … Clomethiazole
Products Clorazepate is commercially available in the form of capsules and tablets (Tranxilium, generics). It has been approved in many countries since 1971. Structure and properties Clorazepate is present in drugs as dipotassium clorazepate (C16H11ClK2N2O4, Mr = 408.9 g/mol) is present, a white to pale yellow powder that is slightly to very slightly soluble in … Clorazepate
Products Antiepileptic drugs are commercially available in the form of tablets, dispersible tablets, capsules, solutions, suspensions, syrups, as nasal sprays, enemas, and as injectables, among others. Structure and properties The antiepileptic drugs are structurally heterogeneous agents. Within the class, several groups can be identified (see below). Effects The agents have antiepileptic, anticonvulsant, and muscle relaxant … Antiepileptic Drugs
Products Methocarbamol is approved in tablet form (Metoflex). However, it is an older active ingredient, as it was first approved in the United States, for example, in the 1950s. Structure and properties Methocarbamol (C11H15NO5, Mr = 241.2 g/mol) is a carbamate derivative. It exists as a white powder and is sparingly soluble in water. Methocarbamol … Methocarbamol
Products Quinine is approved in many countries in the form of dragées for malaria therapy (quinine sulfate 250 Hänseler). In Germany, film-coated tablets of 200 mg quinine sulfate are commercially available for the treatment of calf cramps (Limptar N). Structure and properties Quinine (C20H24N2O2, Mr = 324.4 g/mol) usually exists as quinine sulfate, a white … Quinine
Products Temazepam is commercially available in capsule form (Normison). It has been approved in many countries since 1983. Structure and properties Temazepam (C16H13ClN2O2, Mr = 300.7 g/mol) is a white crystalline powder that is practically insoluble in water. It is present in drugs as a racemate (hydroxyl group). Temazepam belongs to the 5-aryl-1,4-benzodiazepines. Effects Temazepam … Temazepam
Products Dantrolene is commercially available in capsule form and as a solution for injection (dantamacrine, dantrolene). It has been approved in many countries since 1983. It was developed in the 1960s and 70s. This article refers primarily to peroral therapy. Structure and properties Dantrolene (C14H10N4O5, Mr = 314.3 g/mol) is present in the drug as … Dantrolene
Products Z-drugs – they are also called Z-substances – are usually taken in the form of film-coated tablets. In addition, other dosage forms such as sustained-release tablets and effervescent tablets are commercially available. Zolpidem (Stilnox) was the first substance from this group to be approved in many countries in 1990. In the literature, alluding to … Z-Drugs
Products Dronabinol is an anesthetic. The Federal Office of Public Health may grant an exemption for limited medical use. Pharmacies can make dronabinol preparations themselves as an extemporaneous prescription or have them made by contract manufacturing. There are two provisions in the new formulary: Oily dronabinol drops 2.5% (NRF 22.8). Dronabinol capsules 2.5 mg, 5 … Dronabinol