Symptoms Drug-induced prolongation of the QT interval can rarely lead to severe arrhythmias. This is polymorphic ventricular tachycardia, known as torsade de pointes arrhythmia. It can be seen on the ECG as a wave-like structure. Due to the dysfunction, the heart cannot maintain blood pressure and can only pump insufficient blood and oxygen to the … Prolongation of the QT Interval
Ondansetron is a major antiemetic that belongs to the setrone class of drugs. Ondansetron achieves its effects by causing inhibition of 5HT3 receptors. Because of this mode of action, ondansetron is also considered a serotonin receptor antagonist. The drug is marketed under the trade name Zofran and is used to treat nausea, vomiting, and emesis. … Ondansetron: Effects, Uses & Risks
Symptoms The main symptoms are diarrhea with watery stools, cramps in the lower abdomen, and flushing, which is seizure-like severe facial redness or purplishness, although the neck or legs may also be affected. The untreated or undiagnosed disease can lead to valvular heart defect, telangiectasias, and pellagra (vitamin B2 deficiency). Causes Carcinoid syndrome is based … Carcinoid Syndrome
Products Ondansetron is commercially available in the form of film-coated tablets, meltable tablets (lingual tablets), as a syrup, and as an infusion/injection preparation. In addition to the original Zofran, generic versions are also available. Ondansetron was introduced in 1991 as the first active ingredient from the group of 5-HT3 receptor antagonists was approved. Structure and … Ondansetron
Products Antiemetics are commercially available in the form of tablets, as melting tablets, as solutions (drops), and injectables, among others. They are also administered as suppositories because peroral administration is not possible. In many countries, the best-known antiemetics include domperidone (Motilium, generic) and meclozine, which, along with caffeine and pyridoxine, is contained in Itinerol B6. … Antiemetics: Drugs against Nausea or Vomiting
Symptoms Complaints include nausea and/or vomiting, which in a minority occur only in the morning, and in the majority also during the day. Because of throat irritation, additional throat clearing and coughing are often observed and, in a severe course, tightening of the rib muscles. Course For most pregnant women, normal, self-limiting symptoms with no … Pregnancy Vomiting
Symptoms Rosacea is a chronic inflammatory skin disorder of the face that typically affects the cheeks, nose, chin, and central forehead symmetrically (Figure). The skin around the eyes is left out. It occurs more often in people with fair skin and in middle age, but it can occur in any skin type and at any … Rosacea Causes and Treatment
Products Serotonin receptor antagonists are commercially available in the form of film-coated tablets, melting tablets, soft capsules, as syrups, and as infusion/injection preparations. This article refers to the setrone (5-HT3 receptor antagonists), which are used as antiemetics. The first agent from this group to be approved in the United States was ondansetron (Zofran) in 1991, … Serotonin Antagonists (Setrone)
Symptoms Nausea is an unpleasant and painless sensation that can lead to vomiting. Vomiting is an autonomic response of the body in which the stomach contents are expelled through the mouth with contraction of the muscles. Its primary purpose is to protect the body from toxic and inedible foods and harmful substances. Nausea may be … Nausea and Vomiting
P-glycoprotein P-glycoprotein (P-gp, MDR1) is a primary active efflux transporter with a molecular weight of 170 kDa, belonging to the ABC superfamily and consisting of 1280 amino acids. P-gp is the product of the -gene (formerly: ). P is for , ABC is for . Occurrence P-glycoprotein is found on various tissues of the human … P-Glycoprotein
