Products Nabumetone was commercially available in many countries in the form of film-coated tablets and soluble tablets (Balmox). It was approved in 1992 and went out of commerce in 2013, presumably for commercial reasons. Structure and properties Nabumetone (C15H16O2, Mr = 228.3 g/mol) exists as a white crystalline powder that is practically insoluble in water. … Nabumetone
Products Benzhydrocodone was approved in the United States in 2018 as a fixed combination with acetaminophen in tablet form with a modified release of active ingredient (Apadaz). Structure and properties Benzhydrocodone (C25H25NO4, Mr = 403.5 g/mol) is an inactive prodrug of hydrocodone. It is an ester of benzoic acid with the opioid that is enzymatically … Benzhydrocodone
Products Bisacodyl is commercially available in the form of enteric-coated tablets (dragées) and suppositories (Dulcolax, generics). It has been approved in many countries since 1957. Structure and properties Bisacodyl (C22H19NO4, Mr = 361.39 g/mol) exists as a white crystalline powder that is practically insoluble in water. It is a diphenylmethane and triarylmethane derivative. Bisacodyl is … Bisacodyl
Products The fixed combination Pylera with the active ingredients bismuth, metronidazole, and tetracycline was approved in many countries in 2017 in the form of hard capsules. In some countries, it was available much earlier, for example, in the United States since 2006. This treatment is the so-called bismuth quadruple therapy (“BMTO”), which was developed by … Bismuth, Metronidazole, Tetracycline
Products Aminolevulinic acid is commercially available as patches and gels (Alacare, Ameluz). Structure and properties The 5-aminolevulinic acid (C5H9NO3, Mr = 131.1 g/mol) is a nonproteinogenic amino acid. It exists in the drug as a hydrochloride, a white crystalline solid that is soluble in water. Effects 5-Aminolevulinic acid (ATC L01XD04) is phototoxic and causes destruction … 5-Aminolevulinic Acid
Products Benfotiamine is commercially available in Germany in the form of film-coated tablets, among others. It is usually combined fixed with vitamin B6 (pyridoxine). In many countries, benfotiamine is not registered. Structure and properties Benfotiamine (C19H23N4O6PS, Mr = 466.4 g/mol) is a lipophilic prodrug of thiamine (vitamin B1). It is dephosphorylated in the intestine to … Benfotiamine
Products Sulfasalazine is commercially available as tablets and as dragées with an enteric coating (salazopyrin, salazopyrin EN, some countries: azulfidine, azulfidine EN, or RA). It has been approved in many countries since 1950. EN stands for enteric coated and RA for Rheumatoid Arthritis. EN dragées have a coating to prevent irritation and improve gastric tolerance. … Sulfasalazine: Drug Effects, Side Effects, Dosage and Uses
Products Netobimin is commercially available as an oral suspension for animals. It has been approved in many countries since 1989. Structure and properties Netobimin (C14H20N4O7S2, Mr = 420.5 g/mol) is a prodrug of albendazole. Effects Netobimin (ATCvet QP52AC06) has antihelminthic properties. Indications For treatment of infestations of gastrointestinal nematodes, lungworms, tapeworms, and liver flukes in … Netobimin
Products Neuraminidase inhibitors are commercially available in the form of capsules, powder for oral suspension, powder inhalers, and injectables. The first agents to be approved were zanamivir (Relenza) in 1999, followed by oseltamivir (Tamiflu). Laninamivir (Inavir) was released in Japan in 2010 and Peramivir (Rapivab) in the USA in 2014. The public is most familiar … Neuraminidase Inhibitor
Products Dexpanthenol is commercially available in the form of creams, ointments (wound healing ointments), gels, lotions, solutions, lip balms, eye drops, nasal sprays, nasal ointments and foams, among others (selection). These are approved drugs, cosmetics and medical devices. Creams and ointments typically contain 5% of the active ingredient. The best-known brand containing the ingredient is … Dexpanthenol
Products Lymecycline is commercially available in the form of capsules (Tetralysal). It was approved in many countries in 2005. Structure and properties Lymecycline (C29H38N4O10, Mr = 602.6 g/mol) is a water-soluble prodrug of the antibiotic tetracycline with the amino acid lysine. Lymecycline is better absorbed than tetracycline. Effects Lymecycline (ATC J01AA04) has bacteriostatic properties against … Lymecycline
Products Abacavir is commercially available as film-coated tablets and as an oral solution (Ziagen, combination products). It has been approved in many countries since 1999. Generic versions are approved. Structure and properties Abacavir (C14H18N6O, Mr = 286.3 g/mol) is present in drugs, among other forms, as abacavir sulfate, a white crystalline powder that is soluble … Abacavir
