Products Etanercept is commercially available as a solution for injection (Enbrel, biosimilars). It has been approved in many countries since 2000. The biosimilars Benepali and Erlezi were approved in many countries in 2018. Structure and properties Etanercept is a dimeric fusion protein composed of the extracellular ligand-binding domain of TNF receptor-2 and the Fc domain … Etanercept
Products Gold compounds are commercially available (worldwide) in the form of capsules and injection solutions (e.g., Ridaura, Tauredon), among others. They are rarely used medicinally today. Structure and properties Elemental gold (Latin: aurum, abbreviation: Au, M. r = 96.97 g/mol, atomic number 79) is a chemical element and a lustrous noble metal with a yellow … Gold
When do I have to go to the doctor? Since rheumatism is a disease that can lead to inflammation of various organs, timely treatment is very important. Therefore, if a rheumatic disease is suspected, it is recommended to consult a doctor. Indications of rheumatism can be an increased stiffness of the joints in the morning … When do I have to go to the doctor? | Home remedy against rheumatism
Rheumatism is a broad term that encompasses various diseases. It is therefore also referred to as rheumatoid diseases, which includes rheumatoid arthritis, for example. This clinical picture includes the typical knotty changes of the hands, which for many people is the first association with rheumatism. It also causes muscle pain, slight fever and inflammation of … Home remedy against rheumatism
How often and how long should I use the household remedies? The application of the household remedies can be of varying duration depending on the type of household remedy. The use of household remedies should always be adapted to the severity of the symptoms and reduced accordingly in the event of relief. Omega-3 fatty acids … How often and how long should I use the household remedies? | Home remedy against rheumatism
What should be avoided? With rheumatism it is not beneficial to avoid sports and exercise. On the contrary, it is important to avoid absolute physical protection, because this leads to increased stiffness of the joints and further restriction of mobility. In addition, certain foods should be avoided. These include above all meat, corn, wheat, coffee … What should be avoided? | Home remedy against rheumatism
Products Anakinra is marketed as a solution for injection in a prefilled syringe (Kineret). The drug has not yet been approved in many countries. Structure and properties Anakinra is a recombinant, nonglycosylated human interleukin-1 receptor antagonist. It differs from natural IL-1Ra in having an additional methionine at the N terminus. Anakinra consists of 153 amino … Anakinra
Products Methotrexate is commercially available as a solution for parenteral use and in tablet form. See also under methotrexate prefilled syringe (low-dose). Structure and properties Methotrexate (C20H22N8O5, Mr = 454.44 g/mol) is a dicarboxylic acid that exists as a yellow to orange crystalline powder that is virtually insoluble in water. Methotrexate was developed as a … Methotrexate: Drug Effects, Side Effects, Dosage and Uses
Products Prefilled methotrexate syringes have been approved in many countries since 2005 (Metoject, generic). They contain between 7.5 to 30 mg of active ingredient, in increments of 2.5 mg. The dose is much lower than for chemotherapy (“low-dose methotrexate“). The syringes are stored at room temperature between 15 to 25 °C and protected from light. … Methotrexate Ready-To-Use Syringe
Background Kinases (phosphotransferases) are a large family of enzymes involved in the transduction and amplification of signals on and in cells. They exert their effects by phosphorylating their substrates, that is, by adding a phosphate group to the molecules (Figure). Kinases have complicated names that are usually abbreviated: ALK, AXL, BCR-ABL, c-Kit, c-Met, ERBB, EGFR, … Kinase Inhibitors
Products Ciclosporin is commercially available as capsules, a drinkable solution, and an infusion concentrate (Sandimmune, Sandimmune Neoral, generics). It has been approved in many countries since 1995. Neoral is the microemulsion formulation that has more stable bioavailability than traditional Sandimmune. In 2016, ciclosporin eye drops were approved (see there). Structure and properties Ciclosporin (C62H111N11O12, Mr … Ciclosporin
Flexible dosage By dividing, the fixed dose of tablets can be changed, which increases flexibility. This is because a dose reduction may be necessary for children, for patients with renal insufficiency, for drug interactions, or for altered drug metabolism. Tablets are also divided for economic reasons. For example, the duration of therapy may be doubled … Divisibility of Tablets
