spironolactone

Spironolactone: Effects, Applications, Side Effects

How spironolactone works Spironolactone is an active substance from the class of aldosterone inhibitors (antagonist). It blocks the action of the hormone aldosterone and thus has antihypertensive, antiandrogenic and mild diuretic (diuretic) properties. The blood is filtered through the renal corpuscle, retaining larger components such as proteins or whole blood cells and filtering out smaller … Spironolactone: Effects, Applications, Side Effects

Erectile Dysfunction: Causes and Treatment

Symptoms Erectile dysfunction or so-called erectile dysfunction refers to the persistent or recurrent inability to achieve or maintain an erection, which is necessary for sexual activity. This makes sexual intercourse impossible and severely limits sexual life. For the affected man, erectile dysfunction can be a great psychological burden. It can trigger stress, negatively affect self-esteem … Erectile Dysfunction: Causes and Treatment

Potassium Health Benefits

Products Potassium is commercially available, among other things, in the form of effervescent tablets (so-called effervettes), as sustained-release dragées and sustained-release tablets (e.g., Kalium Hausmann, KCl-retard, Plus Kalium). It is also contained in sports drinks such as Isostar or Sponser. The dose is usually expressed in millimoles (mmol) or milliequivalents (mEq): 1 mmol = 39.1 … Potassium Health Benefits

Antiandrogens

Products Antiandrogens are mainly commercially available in the form of tablets, capsules, and injectables. Among the first steroidal agents was cyproterone acetate, which was patented in the 1960s. Flutamide was the first non-steroidal agent to be approved in the 1980s. Structure and properties A distinction is made between antiandrogens with a steroidal structure (like the … Antiandrogens

Renin-Angiotensin-Aldosterone System (RAAS)

Effects The RAAS is activated in the presence of low blood pressure, decreased blood volume, hyponatremia, and sympathetic activation. Main actions: mediated via angiotensin II: Vasoconstriction Blood pressure increase Release of catecholamines Hypertrophy at the heart Mediated via aldosterone: Water and sodium ions are retained Potassium ions and protons are eliminated Overview of the RAAS … Renin-Angiotensin-Aldosterone System (RAAS)

Canrenon

Products Canrenone is commercially available as an injectable (Soldactone). It has been approved in many countries since 1975. Structure and properties Canrenone (C22H28O3, Mr = 340.5 g/mol) is an active metabolite of spironolactone (aldactone) and, unlike the latter, is soluble in water. Canrenone is present in drugs as potassium canrenoate, the potassium salt of canrenoic … Canrenon

Torasemide

Products Torasemide is commercially available in tablet form (Torem, generic). It has been approved in many countries since 1993. Structure and properties Torasemide (C16H20N4O3S, Mr = 348.4 g/mol) exists as a white powder that is practically insoluble in water. It is a pyridine-sulfonylurea derivative. Torasemide differs structurally from its precursor furosemide (Lasix, generics), a sulfonamide. … Torasemide

Interactions

Definition When two or more drugs are combined, they may affect each other. This is especially true with regard to their pharmacokinetics (ADME) and effects and adverse effects (pharmacodynamics). This phenomenon is called interaction and drug-drug interaction. Interactions are usually undesirable because they can lead to, for example, loss of efficacy, side effects, poisoning, hospitalization, … Interactions

Potassium-Sparing Diuretics

Effects Diuretic Potassium retaining Mechanism of action Blockade of sodium channels in the collecting tube of the nephron. Agents See under: Aldosterone antagonists, e.g., spironolactone. Amiloride Triamterene (out of commerce)

Drospirenone

Products Drospirenone is commercially available as a fixed combination with ethinyl estradiol for contraception in the form of film-coated tablets (Yasmin, Yasminelle, YAZ, generics, auto-generics). Drospirenone is also used in combination with estradiol for hormone replacement therapy (Angeliq). Bayer’s originals Yasmin, Yasminelle and YAZ will go off the market in many countries in December 2021. … Drospirenone

Agranulocytosis Symptoms and Treatment

Symptoms Typical symptoms of agranulocytosis include fever, chills, feeling ill, tonsillitis, sore throat, difficulty swallowing, and lesions and bleeding of the oral, nasal, pharyngeal, genital, or anal mucosa. The disease can lead to dangerous infections and blood poisoning and, if left untreated, can relatively often be fatal. Agranulocytosis usually occurs rarely to very rarely as … Agranulocytosis Symptoms and Treatment