spironolactone

Diuretics (Water Pills): Effects, Side Effects, Dosage and Uses

Products Diuretics are mainly administered in the form of tablets. In addition, injectables are also commercially available. Among the most commonly prescribed diuretics are loop diuretics (torasemide). Effects Diuretics (ATC C03) have diuretic and antihypertensive properties. Through various mechanisms, they cause increased excretion of water and electrolytes in the urine. They are active at the … Diuretics (Water Pills): Effects, Side Effects, Dosage and Uses

Furosemide: Drug Effects, Side Effects, Dosage and Uses

Products Furosemide is commercially available in the form of tablets, sustained-release capsules, and as a solution for injection (Lasix, generics). It has been approved in many countries since 1964 and is also used in fixed combination with the aldosterone antagonist spironolactone (Lasilactone, generic). Structure and properties Furosemide (C12H11ClN2O5S, Mr = 330.7 g/mol) exists as a … Furosemide: Drug Effects, Side Effects, Dosage and Uses

Conn Syndrome

Definition-What is Conn syndrome? Conn syndrome, also known as primary hyperaldosteronism, is caused by a pathological change in the adrenal cortex, which leads to an overproduction of the messenger substance aldosterone. Aldosterone is a hormone which has an important function in the regulation of the human salt and water balance. It sometimes plays a decisive … Conn Syndrome

I recognize Conn syndrome from these symptoms | Conn Syndrome

I recognize Conn syndrome from these symptoms The main symptoms of Conn syndrome are therapy-resistant high blood pressure and a low blood potassium level. High blood pressure can lead to headache and dizziness. Furthermore, sleep disturbances, tiredness, nervousness and concentration problems can be observed in those affected. The low potassium content, a so-called hypokalemia, can … I recognize Conn syndrome from these symptoms | Conn Syndrome

Conn syndrome in the cat | Conn Syndrome

Conn syndrome in the cat Conn syndrome in cats is caused by a disorder or disease of the adrenal cortex. As in humans, there are basically two causes: overproduction of aldosterone through hyperplasia, which means that the tissue cells multiply or a tumour, which is usually benign, is called an adenoma. The excess aldosterone also … Conn syndrome in the cat | Conn Syndrome

Spironolactone

Products Spironolactone is commercially available in film-coated tablet form as a monopreparation (Aldactone) and in fixed combination with furosemide (Furospir). It was developed in the 1950s at G.D. Searle in Chicago and approved in 1959, and in many countries in 1961. Structure and properties Spironolactone (C24H32O4S, Mr = 416.6 g/mol) exists as a white to … Spironolactone

Buticide

Products Butizide was marketed exclusively in combination with spironolactone in the form of film-coated tablets (Aldozone). It had been approved in many countries since 1968. Structure and properties Buticide (C11H16ClN3O4S2, Mr = 353.8 g/mol) Effects Buticide (ATC C03EA14) has diuretic properties. Indications In combination with spironolactone: Heart failure Liver cirrhosis with ascites and/or edema. Nephrotic … Buticide

Hyperkalemia (High Potassium)

Background Potassium ions play an important role in many biological processes, particularly in the generation of membrane and action potentials and electrical conduction in nerve cells and the heart. Potassium is 98% localized intracellularly. The primary active transporter Na+/K+-ATPase provides transport into cells. Two hormones maintain the deep extracellular potassium concentration. The first is insulin, … Hyperkalemia (High Potassium)

Progestins

Products Progestogens are commercially available in the form of tablets, capsules, transdermal patches and gels, vaginal rings, injectables, and vaginal preparations, among others. They are contained in hormonal contraceptives, on the one hand in mono- and on the other hand in combination preparations. Structure and properties Progestins are steroid hormones. The lead substance is the … Progestins

Premenstrual Syndrome

Symptoms Premenstrual syndrome is a syndrome occurring in women with psychological and physical symptoms that occur in the run-up to menstruation (luteal phase) and disappear at the beginning of menstruation. It is not the menstrual symptoms that occur during menstruation. Depression, anger, irritability, anxiety, confusion, lack of concentration, insomnia, increased appetite, craving for sweets, tightness … Premenstrual Syndrome

Clascoteron

Products Clascoterone was approved as a cream in the United States in 2020 (Winlevi). Structure and properties Clascoterone (C24H34O5, Mr = 402.5 g/mol) corresponds to the steroid cortexolone-17α-propionate. It exists as a white powder that is practically insoluble in water. Effects Clascoterone has antiandrogenic properties. The effects are due to antagonism at androgen receptors. Androgens … Clascoteron

Spironolactone: Effects, Uses & Risks

Spironolactone is a so-called competitive antagonist to the receptor for mineralocorticoids. The active ingredient spironolactone belongs to the pharmacological group of diuretics, which have potassium-sparing properties. The drug counts as an essential drug on the WHO list. What is spironolactone? Spironolactone causes increased flushing of water from the body. Spironolactone is a pharmacological agent that … Spironolactone: Effects, Uses & Risks