Interview with Markus Look, MD, internist from Bonn, Germany, and author of the report of the Drug Commission of the German Medical Association (AKDÄ) on statins and Q10. In a statement for the AKDÄ, Dr. Look compiled the existing knowledge about the connection between the intake of cholesterol-lowering drugs from the current family of statins … Statins and Q10: Interview with Dr. Med Look
Products Most statins are commercially available in the form of film-coated tablets, and some are also available as capsules. The first active ingredient to be marketed was lovastatin from Merck in the United States in 1987. In many countries, simvastatin (Zocor) and, shortly thereafter, pravastatin (Selipran) were the first agents to be approved in 1990. … Statins
Products Medicinal mushrooms are commercially available, for example, in the form of capsules, tablets and as powders as dietary supplements or as individually prepared mixtures. Also used are the pure ingredients that are extracted, synthetically produced or semi-synthetically modified. These are usually registered as medicinal products. About mushrooms Fungi are a very diverse group of … Medicinal Mushrooms
Products Evolocumab was approved in the EU and US in 2015 and in many countries in 2016 in the form of a solution for injection (Repatha). Structure and properties Evolocumab is a human IgG2 monoclonal antibody with a molecular mass of 141.8 kDa. It is produced by biotechnological methods. Effects Evolocumab (ATC C10AX13) has lipid-lowering … Evolocumab
Products Coenzyme Q10 is commercially available as a dietary supplement in the form of capsules and drops, among other products. It is also found in cosmetics. As a drug, Q10 has not yet been registered in many countries. The short-chain analogue idebenone is approved as a drug. Structure and properties Coenzyme Q10 (C59H90O4, Mr = … Coenzyme Q10
Products Medicines containing colchicine are no longer on the market in many countries. Drugs are available abroad that can be imported. It may also be possible to prepare an extemporaneous formulation in a pharmacy (difficulties: toxicity, substance). Stem plant Colchicine is the main alkaloid of the autumn crocus (Colchicaceae), which contains it particularly abundantly in … Colchicine
Products Lipid-lowering agents are mainly sold as tablets and capsules as monopreparations and combination preparations. Some other dosage forms exist, such as granules and injectables. Statins have established themselves as the most important group at present. Structure and properties The chemical structure of lipid-lowering agents is inconsistent. However, within the class, groups with comparable structures … Lipid-Lowering Agents
Symptoms The possible symptoms of a transient ischemic attack (TIA) include: Visual disturbances, temporary blindness Difficulty swallowing Sensory disturbances such as numbness or formication. Speech disorders Coordination disorders, loss of balance, paralysis. Behavioral disturbances, fatigue, drowsiness, agitation, psychosis, memory impairment. The symptoms occur suddenly, are transient and last only briefly, during a maximum of one … Transient Ischemic Attack
Products Pravastatin is commercially available in tablet form (Selipran, generics). It has been approved in many countries since 1990. Structure and properties Pravastatin (C23H36O7, Mr = 424.5 g/mol) is present in drugs as pravastatin sodium, a white to yellowish-white powder or crystalline powder that is readily soluble in water. It is not a prodrug, unlike … Pravastatin
Products Gemfibrozil is commercially available in the form of film-coated tablets (Gevilon, Gevilon Uno). It has been approved in many countries since 1985. Structure and properties Gemfibrozil (C15H22O3, Mr = 250.3 g/mol) exists as a white powder that is practically insoluble in water. Effects Gemfibrozil (ATC C10AB04) has lipid-lowering properties. It lowers VLDL, triglycerides, total … Gemfibrozil
Single administration Many medications are administered daily over a long period of time, such as agents for high blood pressure or lipid-lowering agents such as statins for disorders of lipid metabolism. However, various drugs also exist for which a single dose, i.e., a single administration, is sufficient. If necessary, it can be repeated after a … Single Dose
Background That grapefruit juice can cause drug-drug interactions was discovered by chance in a clinical trial in 1989 and confirmed in an experiment by the same research group in 1991 (Bailey et al, 1989, 1991). This showed that simultaneous ingestion of grapefruit juice with the calcium channel blocker felodipine significantly increases the bioavailability of felodipine. … Interactions with Grapefruit Juice