Products Nicotinic acid was commercially available in the form of modified-release tablets as a fixed combination with laropiprant (Tredaptive, 1000 mg/20 mg). The combination was approved in many countries in 2009, replacing earlier monopreparations such as Niaspan. The drug was withdrawn from the market on January 31, 2013. Structure and properties Nicotinic acid (C5H5NO2, Mr … Nicotinic Acid
Definition Onset of action is the time at which the effect of a drug becomes observable or measurable. There is a delay between the administration of the drug (application) and the onset of action. We refer to this period of time as the latency period. It is in the range of minutes, hours, days, or … Onset of Action
Introduction Breast cancer resistance protein (BCRP or ABCG2) is an efflux transporter that belongs to the ABC superfamily (ATP-binding cassette). It is encoded by the gene first isolated from breast cancer cells in 1998. BCRP consists of 655 amino acids and has a molecular weight of 72 kDa. BCRP mediates resistance to structurally and pharmacologically … BCRP
Products Erythromycin is commercially available for peroral administration in tablet and granular form (Erythrocin / Erythrocin ES). This article refers to the drugs intended for ingestion. Erythromycin was first approved in the 1950s. Structure and properties Erythromycin is a natural substance produced by the bacterium (formerly: ). In oral medications, it is present as erythromycin … Erythromycin
Symptoms Photosensitivity often manifests like sunburn in extensive skin redness, pain, a burning sensation, blistering, and hyperpigmentation after healing. Other possible skin reactions include eczema, itching, urticaria, telangiectasia, tingling, and edema. The nails may also be affected less frequently and may peel off in front (photoonycholysis). The symptoms are limited to the areas of the … Photosensitivity
Products Lovastatin is not commercially available in many countries. Structure and properties Lovastatin (C24H36O5, Mr = 404.5 g/mol) exists as a white crystalline powder that is insoluble in water. Effects Lovastatin is lipid-lowering. Indications Dyslipidemia
Symptoms Nighttime calf cramps are painful and involuntary muscle contractions of the legs that often occur in the calves and feet. They last only a few minutes but can continue to cause discomfort for hours. They are particularly common in older people over 60 years of age. They are benign complaints. The most important complication … Nocturnal Calf Cramps
Products Rosuvastatin is commercially available in the form of film-coated tablets (Crestor, generic, auto-generic). It was approved in many countries in 2006 (Netherlands: 2002, EU and US: 2003). The marketing authorization holder is AstraZeneca. The statin was originally developed at Shionogi in Japan. In the USA, generic versions came on the market in 2016. In … Rosuvastatin
Products Red mold rice is commercially available in some countries as a dietary supplement or food. In 2014 and 2019, Swissmedic informed that the sale of products with is not allowed in many countries, either as medicines or dietary supplements. Ingredients Red mold rice is a fermentation product of rice with mold strains of the … Red Mold Rice
Products Lomitapide is commercially available in capsule form (Juxtapid, Lojuxta). It was approved in the United States in 2012 and in the EU in 2013. The drug has not yet been registered in many countries. Structure and properties Lomitapide (C39H37F6N3O2, Mr = 693.7 g/mol) is present in the drug as lomitapide mesilate, a white powder … Lomitapide
Products Ciprofibrate was commercially available in many countries in capsule form (Hyperlipen, off label). It was approved in 1993 and has not been available since 2013. Structure and properties Ciprofibrate (C13H14Cl2O3, Mr = 289.2 g/mol) is a racemate and a phenoxyisobutyric acid derivative. It exists as a white to pale yellow powder that is practically … Ciprofibrate
Products Fluvastatin is commercially available in the form of capsules and sustained-release generic tablets (generics). It has been approved in many countries since 1993. Sales of the original Lescol were discontinued by Novartis in 2018. Structure and properties Fluvastatin (C24H26FNO4, Mr = 411.5 g/mol) is present in drugs as fluvastatin sodium, a white or pale … Fluvastatin
