Products Sympatholytics are commercially available in the form of tablets, capsules, as injectables, and eye drops, among others. Effects Sympatholytics have sympatholytic properties, meaning that they abolish the effects of the sympathetic nervous system, a portion of the autonomic nervous system. Their effects are usually due to direct antagonism at adrenoceptors. Indirect sympatholytics reduce the … Sympatholytics
Products Beta-blockers are available in many countries in the form of tablets, film-coated tablets, sustained-release tablets, as capsules, solution, eye drops, and as injection and infusion solutions. Propranolol (Inderal) was the first representative of this group to appear on the market in the mid-1960s. Today, the most important active ingredients include atenolol, bisoprolol, metoprolol and … Beta Blocker Effects and Side Effects
Products Sympathomimetics are commercially available, for example, in the form of tablets, capsules, granules, injectable solutions, eye drops, and nasal sprays. Structure and properties Sympathomimetics are structurally derived from the natural neurotransmitters epinephrine and norepinephrine. Effects Sympathomimetics have sympathomimetic properties, meaning that they promote the effects of the sympathetic nervous system, a portion of the … Sympathomimetics
Products Alfuzosin is commercially available in sustained-release tablet form and has been approved in many countries since 1994. In addition to the original Xatral, generic versions are also available. Structure and properties Alfuzosin (C19H27N5O4, Mr = 389.45 g/mol) is a quinazoline derivative. It is present in drugs as alfuzosin hydrochloride, a white crystalline powder that … Alfuzosin
Products No finished drug products containing tolazoline are on the market in many countries. Structure and properties Tolazoline (C10H12N2, Mr = 160.2 g/mol) Effects Tolazoline (ATC C04AB02, ATC M02AX02) is α-sympatholytic and vasodilatory.
Products Clonidine is commercially available in many countries as tablets and as a solution for injection and has been approved since 1970 (Catapresan). In some countries, clonidine is approved for the treatment of ADHD (eg, Kapvay sustained-release tablets). This article refers to its use in ADHD. Structure and Properties Clonidine (C9H9Cl2N3, Mr = 230.1 g/mol) … Clonidine: Drug Effects, Side Effects, Dosage and Uses
Products Labetalol is commercially available in tablet form and as a solution for injection (Trandate). It has been approved in many countries since 1978. Structure and properties Labetalol (C19H24N2 O3, Mr = 328.4 g/mol) is present in drugs as labetalol hydrochloride, a white powder that is sparingly soluble in water. Effects Labetalol (ATC C07AG01) has … Labetalol
Products Urapidil is commercially available as a solution for injection (Ebrantil). It has been approved in many countries since 1983. Structure and properties Urapidil (C20H29N5O3, Mr = 387.5 g/mol) is a derivative of uracil and piperazine. It is present in drugs as urapidil hydrochloride. Effects Urapidil (ATC C02CA06) has antihypertensive and sympatholytic properties. It lowers … Urapidil
Products Tamsulosin is commercially available in the form of sustained-release tablets and sustained-release capsules and has been approved in many countries since 1996 (Pradif, Pradif T, generics). Tamsulosin is also available as a fixed combination with the 5alpha-reductase inhibitor dutasteride (Duodart), see under dutasteride tamsulosin. In 1996, sustained-release capsules were released (Pradif). Pradif T sustained-release … Tamsulosin
Products Doxazosin is commercially available in the form of sustained-release film-coated tablets (Cardura CR, generic). It has been approved in many countries since 1999. Structure and properties Doxazosin (C23H25N5O5, Mr = 451.5 g/mol) is present in drugs as doxazosin mesilate, a quinazoline derivative and a white crystalline powder that is sparingly soluble in water. Effects … Doxazosin
Products Guanfacine is commercially available in the form of sustained-release tablets (Intuniv). It has been approved in the United States since 2009, in the EU since 2015, and in many countries since 2017. Structure and properties Guanfacine (C9H9Cl2N3O, Mr = 246.1 g/mol) is a phenylacetyl guanidine derivative. It is present in drugs as guanfacine hydrochloride, … Guanfacin
Products Terazosin is commercially available in tablet form (Hytrin BPH) and has been approved in many countries since 1994. It is no longer registered for the treatment of high blood pressure in many countries (formerly Hytrin), but the indication still exists in other countries. Structure and properties Terazosin (C19H25N5O4, Mr = 387.4 g/mol) is a … Terazosin
